R
Roman Renger
Researcher at Max Planck Society
Publications - 8
Citations - 208
Roman Renger is an academic researcher from Max Planck Society. The author has contributed to research in topics: DNA & DNA condensation. The author has an hindex of 3, co-authored 8 publications receiving 62 citations. Previous affiliations of Roman Renger include Dresden University of Technology & German Center for Neurodegenerative Diseases.
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Journal ArticleDOI
HP1 proteins compact DNA into mechanically and positionally stable phase separated domains
Madeline M. Keenen,David Brown,Lucy D Brennan,Roman Renger,Harrison Khoo,Christopher R. Carlson,Bo Huang,Stephan W. Grill,Stephan W. Grill,Geeta J. Narlikar,Sy Redding,Sy Redding +11 more
TL;DR: In this article, the phase-separation by HP1 proteins can explain the biological properties of HP1-mediated heterochromatin, and the authors suggest a generalizable model for genome organization in which a pool of weakly bound proteins collectively capitalize on the polymer properties of DNA to produce self-organizing domains.
Peer ReviewDOI
Author response: HP1 proteins compact DNA into mechanically and positionally stable phase separated domains
Madeline M. Keenen,David Brown,Lucy D Brennan,Roman Renger,Roman Renger,Harrison Khoo,Christopher R. Carlson,Bo Huang,Stephan W. Grill,Stephan W. Grill,Geeta J. Narlikar,Sy Redding,Sy Redding +12 more
Journal ArticleDOI
Kinesin-14 motors drive a right-handed helical motion of antiparallel microtubules around each other
Aniruddha Mitra,Aniruddha Mitra,Aniruddha Mitra,Laura Meißner,Rojapriyadharshini Gandhimathi,Rojapriyadharshini Gandhimathi,Roman Renger,Roman Renger,Felix Ruhnow,Felix Ruhnow,Stefan Diez,Stefan Diez +11 more
TL;DR: 3D in vitro motility assay is developed and utilized and it is found that Ndc’s off-axis motor forces generate torque in antiparallel microtubules which causes microtubule twisting and coiling.
Journal ArticleDOI
Force generation by protein-DNA co-condensation
Thomas Quail,Stefan Golfier,Maria Elsner,Keisuke Ishihara,Vasanthanarayan Murugesan,Roman Renger,Frank Jülicher,Frank Jülicher,Jan Brugués +8 more
TL;DR: The findings show that DNA condensation mediated by transcription factors could bring distant regions of DNA into close proximity, suggesting that this physical mechanism is a possible general regulatory principle for chromatin organization that may be relevant in vivo.
Posted ContentDOI
Co-condensation of proteins with single- and double-stranded DNA
Roman Renger,Roman Renger,Jose A. Morin,Jose A. Morin,Regis P. Lemaitre,Martine Ruer-Gruss,Frank Jülicher,Frank Jülicher,Andreas Hermann,Andreas Hermann,Stephan W. Grill,Stephan W. Grill +11 more
TL;DR: In this article, the authors used optical tweezers to study how the prototypical prion-like protein Fused-in-Sarcoma (FUS) forms liquid-like assemblies in vitro, by co-condensing together with individual single and double stranded DNA molecules.