R
Romina M. Wiedmann
Researcher at Ludwig Maximilian University of Munich
Publications - 7
Citations - 414
Romina M. Wiedmann is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Cancer cell & Anoikis. The author has an hindex of 7, co-authored 7 publications receiving 384 citations. Previous affiliations of Romina M. Wiedmann include University of British Columbia.
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Journal ArticleDOI
The V-ATPase-inhibitor Archazolid abrogates tumor metastasis via inhibition of endocytic activation of the Rho-GTPase Rac1
Romina M. Wiedmann,Karin von Schwarzenberg,Andrea Palamidessi,Laura Schreiner,Rebekka Kubisch,Johanna Liebl,Christina Schempp,Dirk Trauner,György Vereb,Stefan Zahler,Ernst Wagner,Rolf Müller,Giorgio Scita,Angelika M. Vollmar +13 more
TL;DR: The results indicate that archazolid effectively decreases metastatic dissemination of breast tumors by impairing the trafficking and spatially restricted activation of EGFR and Rho-GTPase Rac1, which are pivotal for directed movement of cells.
Journal ArticleDOI
Mode of Cell Death Induction by Pharmacological Vacuolar H+-ATPase (V-ATPase) Inhibition
Karin von Schwarzenberg,Romina M. Wiedmann,Prajakta Oak,Sabine Schulz,Hans Zischka,Gerhard Wanner,Thomas Efferth,Dirk Trauner,Angelika M. Vollmar +8 more
TL;DR: It is concluded that archazolid leads to energy stress which activates adaptive mechanisms like autophagy mediated by HIF1α and finally leads to apoptosis which is proposed as a promising drugable target in cancer therapy caught up at the interplay of apoptosis, Autophagy, and cellular/metabolic stress.
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Hsp27 promotes insulin-like growth factor-I survival signaling in prostate cancer via p90Rsk-dependent phosphorylation and inactivation of BAD.
Amina Zoubeidi,Anousheh Zardan,Romina M. Wiedmann,Jennifer A. Locke,Eliana Beraldi,Ladan Fazli,Martin E. Gleave +6 more
TL;DR: It is reported that Hsp27 expression and phosphorylation levels correlate with IGF-I signaling and castrate-resistant progression in human prostate cancer specimens and cell lines and support targeting HSp27 as a therapeutic strategy for castrate -resistant prostate cancer.
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Cotargeting Stress-Activated Hsp27 and Autophagy as a Combinatorial Strategy to Amplify Endoplasmic Reticular Stress in Prostate Cancer
Masafumi Kumano,Junya Furukawa,Masaki Shiota,Anousheh Zardan,Fan Zhang,Eliana Beraldi,Romina M. Wiedmann,Ladan Fazli,Amina Zoubeidi,Martin E. Gleave +9 more
TL;DR: Findings identify autophagy as a cytoprotective, stress-induced adaptive pathway, activated following disruption of protein homeostasis and ER stress induced by Hsp27 silencing, which illustrates potential benefits of blocking activation of adaptive pathways to improve treatment outcomes in cancer.
Journal ArticleDOI
Pretubulysin: from hypothetical biosynthetic intermediate to potential lead in tumor therapy.
Jennifer Herrmann,Yasser A. Elnakady,Romina M. Wiedmann,Angelika Ullrich,Manfred Rohde,Uli Kazmaier,Angelika M. Vollmar,Rolf Müller +7 more
TL;DR: Pretubulysin induces apoptosis and inhibits cancer cell migration and tubulin assembly in vitro and appears to be an ideal candidate for future development in preclinical trials and a very promising early lead structure in cancer therapy.