R
Ron Dzikowski
Researcher at Hebrew University of Jerusalem
Publications - 66
Citations - 2481
Ron Dzikowski is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Plasmodium falciparum & Gene. The author has an hindex of 26, co-authored 55 publications receiving 2163 citations. Previous affiliations of Ron Dzikowski include Technion – Israel Institute of Technology & Agricultural Research Organization, Volcani Center.
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Journal ArticleDOI
Epigenetic memory at malaria virulence genes
Thanat Chookajorn,Thanat Chookajorn,Ron Dzikowski,Matthias Frank,Matthias Frank,Felomena Li,Alisha Z. Jiwani,Daniel L. Hartl,Kirk W. Deitsch +8 more
TL;DR: Control of var gene transcription and antigenic variation is associated with a chromatin memory that includes methylation of histone H3 at lysine K9 as an epigenetic mark, and how gene transcription memory may affect the mechanism of pathogenesis and immune evasion is discussed.
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Mutually Exclusive Expression of Virulence Genes by Malaria Parasites Is Regulated Independently of Antigen Production
TL;DR: Mutually exclusive expression in P. falciparum is therefore regulated exclusively at the level of transcription, and a functional PfEMP1 protein is not necessary for viability or for proper gene regulation in cultured parasites.
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PfEMP1: an antigen that plays a key role in the pathogenicity and immune evasion of the malaria parasite Plasmodium falciparum.
Noa D. Pasternak,Ron Dzikowski +1 more
TL;DR: PfEMP1 is considered a key player in the pathogenicity of P. falciparum because as the antibody response against the single expressed PfEMP1 develops, small sub-populations of parasites switch expression to alternative forms of Pf EMP1 and re-establish the infection.
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Mechanisms underlying mutually exclusive expression of virulence genes by malaria parasites.
Ron Dzikowski,Felomena Li,Borko Amulic,Andrew Eisberg,Matthias Frank,Matthias Frank,Suchit H. Patel,Thomas E. Wellems,Kirk W. Deitsch +8 more
TL;DR: The results provide the first evidence, to the knowledge, supporting the existence of a postulated var‐specific, subnuclear expression site and reinforce the conclusion that var gene regulation is based on cooperative interactions between the two promoters of each var gene.
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Antisense long noncoding RNAs regulate var gene activation in the malaria parasite Plasmodium falciparum.
Inbar Amit-Avraham,Guy Pozner,Shiri Eshar,Yair Fastman,Netanel Kolevzon,Eylon Yavin,Ron Dzikowski +6 more
TL;DR: It is shown that antisense long noncoding RNAs initiating from var introns are associated with the single active var gene at the time in the cell cycle when the single var upstream promoter is active and played a key role in regulating var gene activation and mutually exclusive expression.