R
Ronald J. deLeeuw
Researcher at University of British Columbia
Publications - 17
Citations - 1943
Ronald J. deLeeuw is an academic researcher from University of British Columbia. The author has contributed to research in topics: Comparative genomic hybridization & Genome. The author has an hindex of 12, co-authored 17 publications receiving 1914 citations.
Papers
More filters
Journal ArticleDOI
A tiling resolution DNA microarray with complete coverage of the human genome.
Adrian Ishkanian,Chad A. Malloff,Spencer Watson,Ronald J. deLeeuw,Bryan Chi,Bradley P. Coe,Antoine M. Snijders,Donna G. Albertson,Daniel Pinkel,Marco A. Marra,Victor Ling,Calum MacAulay,Wan L. Lam +12 more
TL;DR: The constructed tiling resolution array allows comprehensive assessment of genomic integrity and thereby the identification of new genes associated with disease and shows the need to move beyond conventional marker-based genome comparison approaches, that rely on inference of continuity between interval markers.
Journal ArticleDOI
A Comprehensive Analysis of Common Copy-Number Variations in the Human Genome
Kendy K. Wong,Ronald J. deLeeuw,Nirpjit S. Dosanjh,Lindsey R. Kimm,Ze Cheng,Douglas E. Horsman,Calum MacAulay,Raymond T. Ng,Carolyn J. Brown,Evan E. Eichler,Wan L. Lam +10 more
TL;DR: An in-depth survey of CNVs across the human genome provides a valuable baseline for studies involving human genetics and raises the possibility of the contribution of microRNAs to phenotypic diversity in humans.
Journal ArticleDOI
Whole-genome analysis and HLA genotyping of enteropathy-type T-cell lymphoma reveals 2 distinct lymphoma subtypes.
Ronald J. deLeeuw,Andreas Zettl,Erdwine Klinker,Eugenia Haralambieva,Magan Trottier,Raj Chari,Yong Ge,Randy D. Gascoyne,Andreas Chott,Hans–Konrad Müller–Hermelink,Wan L. Lam +10 more
TL;DR: Contrary to current clinical classification, ETL comprises 2 morphologically, clinically, and genetically distinct lymphoma entities; type 2 ETL may not be associated with celiac disease.
Journal ArticleDOI
Characterization of 8p21.3 chromosomal deletions in B-cell lymphoma: TRAIL-R1 and TRAIL-R2 as candidate dosage-dependent tumor suppressor genes
Fanny Rubio-Moscardo,David Blesa,Cinta Mestre,Reiner Siebert,Theodore Balasas,Adalberto Benito,Andreas Rosenwald,Joan Climent,Jose Martinez,Markus Schilhabel,E. Lorraine Karran,Stefan Gesk,Manel Esteller,Ronald J. deLeeuw,Louis M. Staudt,Jose L. Fernandez-Luna,Daniel Pinkel,Martin J. S. Dyer,Jose A. Martinez-Climent +18 more
TL;DR: The data suggest that TRAIL-R1 and TRAil-R2 act as dosage-dependent tumor suppressor genes whose monoallelic deletion can impair TRAIL'sinduced apoptosis in B-cell lymphoma.
Journal ArticleDOI
SeeGH--a software tool for visualization of whole genome array comparative genomic hybridization data.
TL;DR: SeeGH represents a novel software tool used to view and analyze array CGH data that gives users the ability to view the data in an overall genomic view as well as magnify specific chromosomal regions facilitating the precise localization of genetic alterations.