According to W. Edwards Deming, American companies require nothing less than a transformation of management style and of governmental relations with industry. In Out of the Crisis, originally published in 1982, Deming offers a theory of management based on his famous 14 Points for Management. Management's failure to plan for the future, he claims, brings about loss of market, which brings about loss of jobs. Management must be judged not only by the quarterly dividend, but by innovative plans to stay in business, protect investment, ensure future dividends, and provide more jobs through improved product and service. In simple, direct language, he explains the principles of management transformation and how to apply them.

Out of the Crisis

Economic Control of Quality of Manufactured Product.

* Starting from Need* Evolution of the Toyota Production System* Further Development* Genealogy of the Toyota Production System* The True Intention of the Ford System* Surviving the Low-Growth Period

Toyota production system : beyond large-scale production

ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays.

Human CD8+ memory- and effector-type T cells are poorly defined. We show here that, next to a naive compartment, two discrete primed subpopulations can be found within the circulating human CD8+ T cell subset. First, CD45RA−CD45R0+ cells are reminiscent of memory-type T cells in that they express elevated levels of CD95 (Fas) and the integrin family members CD11a, CD18, CD29, CD49d, and CD49e, compared to naive CD8+ T cells, and are able to secrete not only interleukin (IL) 2 but also interferon γ, tumor necrosis factor α, and IL-4. This subset does not exert cytolytic activity without prior in vitro stimulation but does contain virus-specific cytotoxic T lymphocyte (CTL) precursors. A second primed population is characterized by CD45RA expression with concomitant absence of expression of the costimulatory molecules CD27 and CD28. The CD8+CD45RA+CD27− population contains T cells expressing high levels of CD11a, CD11b, CD18, and CD49d, whereas CD62L (L-selectin) is not expressed. These T cells do not secrete IL-2 or -4 but can produce IFN-γ and TNF-α. In accordance with this finding, cells contained within this subpopulation depend for proliferation on exogenous growth factors such as IL-2 and -15. Interestingly, CD8+CD45RA+CD27− cells parallel effector CTLs, as they abundantly express Fas-ligand mRNA, contain perforin and granzyme B, and have high cytolytic activity without in vitro prestimulation. Based on both phenotypic and functional properties, we conclude that memory- and effector-type T cells can be separated as distinct entities within the human CD8+ T cell subset.

/pdf/phenotypic-and-functional-separation-of-memory-and-effector-27jcev1zp1.pdf

Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

Healthcare, as with any other service operation, requires systematic innovation efforts to remain competitive, cost efficient, and up-to-date. This article outlines a methodology and presents examples to illustrate how principles of Lean Thinking and Six Sigma can be combined to provide an effective framework for producing systematic innovation efforts in healthcare. Controlling healthcare cost increases, improving quality, and providing better healthcare are some of the benefits of this approach.

https://ibisuva.nl/assets/publicaties/artikelen/2006-dekoning-lean.pdf

Lean Six Sigma in Healthcare

Limiting dilution assays Experimental design and statistical analysis

The control chart is a very popular tool of statistical process control. It is used to determine the existence of special cause variation to remove it so that the process may be brought in statistical control. Shewhart-type control charts are sensitive for large disturbances in the process, whereas cumulative sum (CUSUM)–type and exponentially weighted moving average (EWMA)–type control charts are intended to spot small and moderate disturbances. In this article, we proposed a mixed EWMA–CUSUM control chart for detecting a shift in the process mean and evaluated its average run lengths. Comparisons of the proposed control chart were made with some representative control charts including the classical CUSUM, classical EWMA, fast initial response CUSUM, fast initial response EWMA, adaptive CUSUM with EWMA-based shift estimator, weighted CUSUM and runs rules–based CUSUM and EWMA. The comparisons revealed that mixing the two charts makes the proposed scheme even more sensitive to the small shifts in the process mean than the other schemes designed for detecting small shifts. Copyright © 2012 John Wiley & Sons, Ltd.

https://ibisuva.nl/assets/publicaties/artikelen/2013-abbas-mixed.pdf

Mixed exponentially weighted moving average-cumulative sum charts for process monitoring

Statistical process control (SPC) is an important application of statistics in which the outputs of production processes are monitored. Control charts are an important tool of SPC. A very popular category is the Shewhart's -chart used to monitor the mean of a process characteristic. Two alternatives to the Shewhart's -chart are the cumulative sum and exponentially weighted moving average (EWMA) charts which are designed to detect moderate and small shifts in the process mean. Targeting on small and moderate shifts in the process mean, we propose an EWMA-type control chart which utilizes a single auxiliary variable. The regression estimation technique for the mean is used in defining the control structure of the proposed chart. It is shown that the proposed chart is performing better than its univariate and bivariate competitors which are also designed for detecting small shifts.

https://ibisuva.nl/assets/publicaties/artikelen/2014-abbas-ewma.pdf

An EWMA-Type Control Chart for Monitoring the Process Mean Using Auxiliary Information

Lean Thinking and Six Sigma are typically considered as separate approaches to process innovation, with complementary strengths. When combined as Lean Six Sigma, this approach provides a unified framework for systematically developing innovations. Lean Six Sigma can also bring about significant results and breakthrough improvements in financial services, as demonstrated with four case studies from Dutch multinational insurance companies. These cases demonstrate the importance of incremental innovations and show that there is room for improvement in the financial services industry. This article takes the integration of Lean Thinking and Six Sigma a step further by providing an integrated framework and a comprehensive roadmap for improvement.

/pdf/lean-six-sigma-in-financial-services-446u2xjs0x.pdf

Ronald J. M. M. Does

Papers

Lean Six Sigma in Healthcare

Limiting dilution assays Experimental design and statistical analysis

Mixed exponentially weighted moving average-cumulative sum charts for process monitoring

An EWMA-Type Control Chart for Monitoring the Process Mean Using Auxiliary Information

Lean Six Sigma in financial services