R
Ronald J. Mandel
Researcher at University of Florida
Publications - 118
Citations - 18488
Ronald J. Mandel is an academic researcher from University of Florida. The author has contributed to research in topics: Substantia nigra & Tyrosine hydroxylase. The author has an hindex of 56, co-authored 118 publications receiving 17602 citations. Previous affiliations of Ronald J. Mandel include University of New Hampshire & University of Illinois at Urbana–Champaign.
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Journal ArticleDOI
A Third-Generation Lentivirus Vector with a Conditional Packaging System
Tom Dull,Romain Zufferey,Michael C. Kelly,Ronald J. Mandel,Matthew Nguyen,Didier Trono,Luigi Naldini +6 more
TL;DR: It is demonstrated that the requirement for the tat gene can be offset by placing constitutive promoters upstream of the vector transcript, and the improved design presented here should facilitate testing of lentivirus vectors.
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Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo.
TL;DR: An HIV vector system in which the virulence genes env, vif, vpr, vpu, and nef have been deleted is described, and this multiply attenuated vector conserved the ability to transduce growth-arrested cells and monocyte-derived macrophages in culture, and could efficiently deliver genes in vivo into adult neurons.
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Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery
Romain Zufferey,Thomas Foster City Dull,Ronald J. Mandel,Anatoly Bukovsky,Dulce Quiroz,Luigi Naldini,Didier Trono +6 more
TL;DR: The inactivation design achieved in this work improves significantly the biosafety of HIV-derived vectors, as it reduces the likelihood that replication-competent retroviruses will originate in the vector producer and target cells, and hampers recombination with wild-type HIV in an infected host.
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Nucleus basalis and thalamic control of neocortical activity in the freely moving rat
TL;DR: It is suggested that the NB system may serve as a structural basis for the concept of the generalized ascending activation of Moruzzi and Magoun (1949) by directly activating the neocortex and by suppressing the rhythm generation in the RT-thalamocortical circuitry.
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Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous system.
Corinna Burger,Oleg S. Gorbatyuk,Margaret J. Velardo,Carmen S. Peden,Philip J. Williams,Sergei Zolotukhin,Paul J. Reier,Ronald J. Mandel,Nicholas Muzyczka +8 more
TL;DR: The tropism and transduction frequency in the central nervous system of three different rAAV vector serotypes are investigated, suggesting that vectors based on distinct AAV serotypes can be chosen for specific applications in the nervous system.