R
Ronald K. Castellano
Researcher at University of Florida
Publications - 99
Citations - 6945
Ronald K. Castellano is an academic researcher from University of Florida. The author has contributed to research in topics: Supramolecular chemistry & Molecule. The author has an hindex of 29, co-authored 91 publications receiving 6369 citations. Previous affiliations of Ronald K. Castellano include Oak Ridge National Laboratory & Scripps Research Institute.
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Interactions with Aromatic Rings in Chemical and Biological Recognition
TL;DR: This review focuses mainly on examples with biological relevance since one of its aims it to enhance the knowledge of molecular recognition forces that is essential for drug development.
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Wechselwirkungen mit aromatischen Ringen in chemischen und biologischen Erkennungsprozessen
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Structure-Based Identification of Small-Molecule Angiotensin-Converting Enzyme 2 Activators as Novel Antihypertensive Agents
Jose A. Hernandez Prada,Anderson J. Ferreira,Michael J. Katovich,Vinayak Shenoy,Yanfei Qi,Robson A.S. Santos,Ronald K. Castellano,Andrew J. Lampkins,Vladimir Gubala,David A. Ostrov,Mohan K. Raizada +10 more
TL;DR: It is concluded that structure-based screening can help identify compounds that activate ACE2, decrease blood pressure, and reverse tissue remodeling and Administration of ACE2 activators may be a valid strategy for antihypertensive therapy.
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Evidence for angiotensin-converting enzyme 2 as a therapeutic target for the prevention of pulmonary hypertension.
Anderson J. Ferreira,Vinayak Shenoy,Yoriko Yamazato,Srinivas Sriramula,Joseph Francis,Lihui Yuan,Ronald K. Castellano,David A. Ostrov,Suk P. Oh,Michael J. Katovich,Mohan K. Raizada +10 more
TL;DR: Conceptual support is provided that activation of ACE2 by a small molecule can be a therapeutically relevant approach for treating and controlling PH.
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Polycaps: Reversibly formed polymeric capsules
TL;DR: These assemblies are assemblies consisting of polymeric capsules, "polycaps," formed from two calix[4]arene tetraureas covalently connected at their lower rims, characterized by 1H NMR spectroscopy through encapsulation of guest species, reversible polymerization, and the formation of sharply defined hybrid capsules.