Showing papers by "Ronald Klein published in 1972"

TL;DR: Subcutaneous administrations of methylmercury hydroxide to male rats markedly reduced the content of microsomal cytochromes P-450 and b 5, and depression of aminopyrine demethylase on a per gram liver basis occurred primarily in the SER.

TL;DR: In whole animal metabolism studies, chlordane pretreatment increased the rate of urinary elimination of carbaryl and carbofuran equivalents andMethylmercury hydroxide, unexpectedly, also increased urinary excretion of both carbamate equivalents and possible mechanisms involved in the enhancement of urinaryexcretion are investigated.

TL;DR: The data suggest that cytochrome P-450 content is reduced by increasing degradation of the fast- phase component and/or decreasing synthesis of the slow-phase component.