R
Ronald Klein
Researcher at University of Wisconsin-Madison
Publications - 1306
Citations - 163459
Ronald Klein is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Population & Diabetes mellitus. The author has an hindex of 194, co-authored 1305 publications receiving 149140 citations. Previous affiliations of Ronald Klein include Los Angeles Biomedical Research Institute & Wake Forest University.
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Journal ArticleDOI
Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study.
Gabriella Tikellis,Cong Sun,Michael B. Gorin,Ronald Klein,Barbara E.K. Klein,Emily K. Marino Larsen,David S. Siscovick,Larry D Hubbard,Tien Yin Wong,Tien Yin Wong +9 more
TL;DR: In this article, the association between the apolipoprotein E (APOE) gene and age-related maculopathy (ARM) in an older population was examined, and the APOE e2 allele was associated with a significant increased risk of late ARM development, whereas the e4 allele may confer some protection.
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Inherited susceptibility to insulin-dependent diabetes is associated with HLA-DR1, while DR5 is protective.
Noel K. Maclaren,William J. Riley,Nicos Skordis,Mark A. Atkinson,Rebecca Spillar,Janet H. Silverstein,Ronald Klein,Constance M. Vadheim,Jerome I. Rotter +8 more
TL;DR: It is concluded that DR1 is an additional risk DR allele for IDD to that of DR3 and DR4, and DR5 an additional protective DR allele to thatof DR2.
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Increased Atherogenic Lipoproteins are Associated With Cognitive Impairment: Effects of Statins and Subclinical Atherosclerosis
Cynthia M. Carlsson,David M. Nondahl,Barbara E.K. Klein,Patrick E. McBride,Mark A. Sager,Carla R. Schubert,Ronald Klein,Karen J. Cruickshanks +7 more
TL;DR: It is suggested that confounding by indication may explain the contradictory findings in studies assessing the association of statins with cognition, and Randomized-controlled clinical trials and longitudinal studies are necessary to determine if statins protect against cognitive decline.
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Tau gene transfer, but not alpha-synuclein, induces both progressive dopamine neuron degeneration and rotational behavior in the rat.
TL;DR: Using a viral vector for mutant (P301L) tau, the effects of gene transfer to the rat substantia nigra in terms of structural and functional properties of dopaminergic neurons are studied, indicating their potential as therapeutic targets for human diseases involving loss of dopamine neurons.
Journal Article
Frailty and Age–related Macular Degeneration. The Beaver Dam Eye Study.
TL;DR: The data suggest that ARM is due to a specific disease process, albeit age-related, rather than to biologic aging, as reflected by measures of frailty, as well as a weak cross-sectional association of handgrip strength with ARM in men.