R
Ronald van Eijk
Researcher at Leiden University Medical Center
Publications - 63
Citations - 5278
Ronald van Eijk is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: KRAS & Cancer. The author has an hindex of 30, co-authored 57 publications receiving 4910 citations. Previous affiliations of Ronald van Eijk include Leiden University.
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Journal ArticleDOI
Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4
Roel A. Ophoff,Gisela M. Terwindt,Monique N. Vergouwe,Ronald van Eijk,Peter J. Oefner,Susan M.G. Hoffman,Jane Lamerdin,Harvey W. Mohrenweiser,Dennis E. Bulman,Maurizio Ferrari,Joost Haan,Dick Lindhout,Gert-Jan B. van Ommen,Marten H. Hofker,Michel D. Ferrari,Rune R. Frants +15 more
TL;DR: A brain-specific P/Q-type Ca2+ channel alpha1-subunit gene, CACNL1A4, covering 300 kb with 47 exons is characterized, revealing polymorphic variations, including a (CA)n-repeat (D19S1150), a (CAG) n-repeat in the 3'-UTR, and different types of deleterious mutations in FHM and EA-2.
Journal ArticleDOI
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome
Twinkal C. Pansuriya,Ronald van Eijk,Pio D'Adamo,Maayke A. J. H. van Ruler,Marieke L. Kuijjer,Jan Oosting,Anne-Marie Cleton-Jansen,Jolieke G. van Oosterwijk,Sofie L. J. Verbeke,Danielle Meijer,Tom van Wezel,Karolin Hansén Nord,Luca Sangiorgi,Berkin Toker,Bernadette Liegl-Atzwanger,Mikel San-Julian,Raf Sciot,Nisha Limaye,Lars-Gunnar Kindblom,Soeren Daugaard,Catherine Godfraind,Laurence M. Boon,Laurence M. Boon,Miikka Vikkula,Miikka Vikkula,Kyle C. Kurek,Karoly Szuhai,Pim J. French,Judith V.M.G. Bovée +28 more
TL;DR: Somatic heterozygous mutations in IDH1 or IDH2 mutations in cartilage tumors were associated with hypermethylation and downregulated expression of several genes and suggested intraneoplastic and somatic mosaicism.
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A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 ( REL ), 8q24.21 and 10p14 ( GATA3 )
Victor Enciso-Mora,Peter Broderick,Yussanne Ma,Ruth F. Jarrett,Henrik Hjalgrim,Kari Hemminki,Anke van den Berg,Bianca Olver,Amy Lloyd,Sara E. Dobbins,Tracy Lightfoot,Flora E. van Leeuwen,Asta Försti,Arjan Diepstra,Annegien Broeks,Jayaram Vijayakrishnan,Lesley Shield,Annette Lake,Dorothy Montgomery,Eve Roman,Andreas Engert,Elke Pogge von Strandmann,Katrin S. Reiners,Ilja M. Nolte,Karin E. Smedby,Hans-Olov Adami,Hans-Olov Adami,Nicola S. Russell,Bengt Glimelius,Bengt Glimelius,Stephen Hamilton-Dutoit,Marieke L. De Bruin,Lars P. Ryder,Daniel Molin,Karina Meden Sørensen,Ellen T. Chang,Ellen T. Chang,Malcolm Taylor,Rosie Cooke,Robert M.W. Hofstra,Helga Westers,Tom van Wezel,Ronald van Eijk,Alan Ashworth,Klaus Rostgaard,Mads Melbye,Anthony J. Swerdlow,Richard S. Houlston +47 more
TL;DR: The role of the major histocompatibility complex in disease etiology is confirmed by revealing a strong human leukocyte antigen (HLA) association and new insight is provided into the pathogenesis of cHL.
Journal ArticleDOI
Rapid KRAS, EGFR, BRAF and PIK3CA mutation analysis of fine needle aspirates from non-small-cell lung cancer using allele-specific qPCR.
Ronald van Eijk,Jappe Licht,Melanie Schrumpf,Mehrdad Talebian Yazdi,Dina Ruano,Giusi Irma Forte,Petra M. Nederlof,Maud Veselic,Klaus F. Rabe,Jouke T. Annema,Vincent T.H.B.M. Smit,Hans Morreau,Tom van Wezel +12 more
TL;DR: It is demonstrated that these standard molecular techniques can be accurately applied on fine needle cytological aspirates from NSCLC patients and show that all mutations detected in the histological material of primary tumor were also identified in the cytological samples.
Journal ArticleDOI
Familial hemiplegic migraine locus on 19p13 is involved in the common forms of migraine with and without aura.
Arne May,Roel A. Ophoff,Gisela M. Terwindt,Christine Urban,Ronald van Eijk,Joost Haan,H. Christoph Diener,Dick Lindhout,Rune R. Frants,Lodewijk A. Sandkuijl,Michel D. Ferrari +10 more
TL;DR: Familial clustering and sibpair analysis showed that affected sibs shared the same marker allele more frequently than expected by chance, suggesting the involvement of a gene on 19p13 in the etiology of the common forms of migraine.