R
Ronald W. Stam
Researcher at Boston Children's Hospital
Publications - 94
Citations - 4006
Ronald W. Stam is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Leukemia & Infant Acute Lymphoblastic Leukemia. The author has an hindex of 30, co-authored 87 publications receiving 3626 citations. Previous affiliations of Ronald W. Stam include Erasmus University Rotterdam & Erasmus University Medical Center.
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Journal ArticleDOI
Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
Guo Wei,Guo Wei,David Twomey,David Twomey,Justin Lamb,Krysta D. Schlis,Jyoti Agarwal,Ronald W. Stam,Joseph T. Opferman,Stephen E. Sallan,Monique L. den Boer,Rob Pieters,Todd R. Golub,Scott A. Armstrong +13 more
TL;DR: Data indicate that MCL1 is an important regulator of GC-induced apoptosis and that the combination of rapamycin and glucocorticoids has potential utility in lymphoid malignancies.
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Inhibition of FLT3 in MLL: Validation of a therapeutic target identified by gene expression based classification
Scott A. Armstrong,Andrew L. Kung,Andrew L. Kung,Meghann E. Mabon,Lewis B. Silverman,Lewis B. Silverman,Ronald W. Stam,Monique L. den Boer,Rob Pieters,John H. Kersey,Stephen E. Sallan,Stephen E. Sallan,Jonathan A. Fletcher,Todd R. Golub,Todd R. Golub,Todd R. Golub,James D. Griffin,James D. Griffin,Stanley J. Korsmeyer,Stanley J. Korsmeyer +19 more
TL;DR: A mouse model of MLL is developed and bioluminescent imaging is used to determine that PKC412 is active against MLL in vivo and proves cytotoxic to Ba/F3 cells dependent upon activated FLT3 containing either mutation.
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In Childhood Acute Lymphoblastic Leukemia, Blasts at Different Stages of Immunophenotypic Maturation Have Stem Cell Properties
Christoph le Viseur,Marc Hotfilder,Simon Bomken,Kerrie Wilson,Silja Röttgers,André Schrauder,Annegret Rosemann,Julie Irving,Ronald W. Stam,Leonard D. Shultz,Jochen Harbott,Heribert Jürgens,Martin Schrappe,Rob Pieters,Josef Vormoor +14 more
TL;DR: Surprisingly, blasts representative of all of the different maturational stages were able to reconstitute and reestablish the complete leukemic phenotype in vivo and inform a model for leukemia-propagating stem cells in childhood ALL.
Journal ArticleDOI
Differential mRNA expression of Ara-C-metabolizing enzymes explains Ara-C sensitivity in MLL gene-rearranged infant acute lymphoblastic leukemia
Ronald W. Stam,Monique L. den Boer,Jules P.P. Meijerink,Marli E. G. Ebus,Godefridus J. Peters,Paul Noordhuis,Gritta Janka-Schaub,Scott A. Armstrong,Stanley J. Korsmeyer,Rob Pieters +9 more
TL;DR: It is concluded that an elevated expression of hENT1, which transports Ara-C across the cell membrane, contributes to Ara- C sensitivity in MLL gene-rearranged infant ALL.
Journal ArticleDOI
Targeting FLT3 in primary MLL-gene–rearranged infant acute lymphoblastic leukemia
Ronald W. Stam,Monique L. den Boer,Pauline Schneider,Peter Nollau,Martin A. Horstmann,H. Berna Beverloo,Ella A M van der Voort,Maria Grazia Valsecchi,Paola De Lorenzo,Stephen E. Sallan,Scott A. Armstrong,Rob Pieters +11 more
TL;DR: FLT3 expression in infants with MLL is demonstrated to be significantly higher compared to both infant and noninfant patients with ALL, suggesting that infant MLL cells displaying activated FLT3 as a result of overexpression can be targeted by FLT 3 inhibitors such as PKC412.