R
Ronan Depoortère
Researcher at Dana Corporation
Publications - 73
Citations - 2788
Ronan Depoortère is an academic researcher from Dana Corporation. The author has contributed to research in topics: Agonist & 5-HT1A receptor. The author has an hindex of 29, co-authored 67 publications receiving 2581 citations.
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Psychopharmacological profile of amisulpride: an antipsychotic drug with presynaptic D2/D3 dopamine receptor antagonist activity and limbic selectivity
TL;DR: This pharmacological profile of amisulpride, characterized by a preferential blockade of effects involving presynaptic mechanisms and limbic structures, may explain the clinical efficacy of this drug against both negative and positive symptoms of schizophrenia and its low propensity to produce extrapyramidal side effects.
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Neurochemical, electrophysiological and pharmacological profiles of the selective inhibitor of the glycine transporter-1 SSR504734, a potential new type of antipsychotic.
Ronan Depoortère,Gihad Dargazanli,Genevieve Estenne-Bouhtou,Annick Coste,Christophe Lanneau,C. Desvignes,Martine Poncelet,Michel Heaulme,Vincent Santucci,Michel Decobert,Annie Cudennec,Carolle Voltz,Denis Boulay,Jean Paul Terranova,Jeanne Stemmelin,Pierre Roger,Benoit Marabout,Mireille Sevrin,Xavier Vigé,Bruno Biton,Régis Steinberg,Dominique Françon,R. Alonso,Patrick Avenet,F. Oury-Donat,Ghislaine Perrault,Guy Griebel,Pascal George,Philippe Soubrie,Bernard Scatton +29 more
TL;DR: SSR504734 is a potent and selective GlyT1 inhibitor, exhibiting activity in schizophrenia, anxiety and depression models, and is expected to be efficacious not only against positive but also negative symptoms, cognitive deficits, and comorbid depression/anxiety states.
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Chronic restraint stress induces mechanical and cold allodynia, and enhances inflammatory pain in rat: Relevance to human stress-associated painful pathologies
TL;DR: This model of prolonged/intermittent restraint stress may be useful in investigating the mechanisms linking stress and pain, and provide an assay to assess the potential therapeutic efficacy of drugs targeted against painful pathologies with a strong stress component, including but not restricted to FM.
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Dopamine D3 receptor agonists produce similar decreases in body temperature and locomotor activity in D3 knock-out and wild-type mice.
TL;DR: Results show that the presence of DA D3 receptors is not necessary for the expression of these effects induced by the three agonists or the antagonist supposedly selective for the D3 receptor subtype, and raises the question of the involvement of the D2-like family member in these behavioural effects and the issue of the in vivo selectivity of these four compounds.
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Dopamine D2 receptor knock-out mice are insensitive to the hypolocomotor and hypothermic effects of dopamine D2/D3 receptor agonists.
TL;DR: The results show that the presence of DA D2 receptors is necessary for the expression of the locomotor- and core temperature-decreasing effects ofDA D2/D3 receptor agonists such as 7-OH-DPAT and PD 128907.