R
Rosa Krajmalnik-Brown
Researcher at Arizona State University
Publications - 161
Citations - 15047
Rosa Krajmalnik-Brown is an academic researcher from Arizona State University. The author has contributed to research in topics: Microbiome & Dehalococcoides. The author has an hindex of 47, co-authored 147 publications receiving 11805 citations. Previous affiliations of Rosa Krajmalnik-Brown include Biodesign Institute & Arizona's Public Universities.
Papers
More filters
Journal ArticleDOI
Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease
Timothy R. Sampson,Justine W. Debelius,Taren Thron,Stefan Janssen,Gauri G. Shastri,Zehra Esra Ilhan,Collin Challis,Catherine E. Schretter,Sandra Rocha,Viviana Gradinaru,Marie-Françoise Chesselet,Ali Keshavarzian,Kathleen M. Shannon,Rosa Krajmalnik-Brown,Pernilla Wittung-Stafshede,Rob Knight,Sarkis K. Mazmanian +16 more
TL;DR: It is reported herein that gut microbiota are required for motor deficits, microglia activation, and αSyn pathology, and suggested that alterations in the human microbiome represent a risk factor for PD.
Journal ArticleDOI
Human gut microbiota in obesity and after gastric bypass
Husen Zhang,John K. DiBaise,Andrea Zuccolo,Dave Kudrna,Michele Braidotti,Yeisoo Yu,Prathap Parameswaran,Michael D. Crowell,Rod A. Wing,Bruce E. Rittmann,Rosa Krajmalnik-Brown +10 more
TL;DR: The coexistence of H2-producing bacteria with relatively high numbers of H1-utilizing methanogenic Archaea in the gastrointestinal tract of obese individuals leads to the hypothesis that interspecies H2 transfer between bacterial and archaeal species is an important mechanism for increasing energy uptake by the human large intestine in obese persons.
Journal ArticleDOI
Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study
Dae Wook Kang,James B. Adams,Ann C. Gregory,Ann C. Gregory,Thomas J. Borody,Lauren Chittick,Lauren Chittick,Alessio Fasano,Alexander Khoruts,Elizabeth Geis,Juan Maldonado,Sharon McDonough-Means,Elena L. Pollard,Simon Roux,Simon Roux,Michael J. Sadowsky,Karen Schwarzberg Lipson,Matthew B. Sullivan,J. Gregory Caporaso,Rosa Krajmalnik-Brown +19 more
TL;DR: This exploratory, extended-duration treatment protocol appears to be a promising approach to alter the gut microbiome and virome and improve GI and behavioral symptoms of ASD.
Journal ArticleDOI
Reduced Incidence of Prevotella and Other Fermenters in Intestinal Microflora of Autistic Children
Dae Wook Kang,Jin Park,Zehra Esra Ilhan,Garrick Wallstrom,Joshua LaBaer,James B. Adams,Rosa Krajmalnik-Brown +6 more
TL;DR: Autism and accompanying GI symptoms were characterized by distinct and less diverse gut microbial compositions with lower levels of Prevotella, Coprococcus, and unclassified Veillonellaceae.
Journal ArticleDOI
Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
Gil Sharon,Nikki Jamie Cruz,Dae Wook Kang,Michael J. Gandal,B. D. Wang,Young-Mo Kim,Erika M. Zink,Cameron P. Casey,Bryn C. Taylor,Christianne J. Lane,Lisa M. Bramer,Nancy G. Isern,David W. Hoyt,Cecilia Noecker,Michael J. Sweredoski,Annie Moradian,Elhanan Borenstein,Janet K. Jansson,Rob Knight,Thomas O. Metz,Carlos Lois,Daniel H. Geschwind,Rosa Krajmalnik-Brown,Sarkis K. Mazmanian +23 more
TL;DR: It is proposed that the gut microbiota regulates behaviors in mice via production of neuroactive metabolites, suggesting that gut-brain connections contribute to the pathophysiology of ASD.