Rossella R. Cacciola

TL;DR: In patients with polycythemia vera, those with a hematocrit target of less than 45% had a significantly lower rate of cardiovascular death and major thrombosis than did those with an intended target of 45 to 50%.

TL;DR: In patients with polycythemia vera and essential thrombocythemia, cytoreduction protects against recurrentThrombosis, particularly after acute coronary syndrome, and the contemporary use of oral anticoagulants or antiplatelet agents further improves the protective effect.

TL;DR: An estimate of the frequency and a detailed characterization of clinically significant HU-related toxicities are provided and have relevance for the management of MPN patients who require second-line therapy after developing H U-related intolerance.

TL;DR: Current understanding of the mechanisms by which pollutants such as diesel exhaust particles (DEP) enhance the underlying allergic inflammatory response, and the evidence that supports the causative link between particulate air pollution from motor vehicles and increasing allergic diseases are reviewed.

TL;DR: Changes in AHR to inhaled methacholine and adenosine 5'-monophosphate (AMP) after budesonide treatment in a randomized, double-blind, placebo-controlled, crossover study of patients with mild-to-moderate asthma underline the exquisite selectivity of diverse surrogate markers of airway inflammation in response to inhaleside.