R
Roxana Ioana Nedelcu
Researcher at Carol Davila University of Medicine and Pharmacy
Publications - 23
Citations - 602
Roxana Ioana Nedelcu is an academic researcher from Carol Davila University of Medicine and Pharmacy. The author has contributed to research in topics: Melanoma & Skin cancer. The author has an hindex of 7, co-authored 20 publications receiving 418 citations.
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Journal ArticleDOI
Germline NLRP1 Mutations Cause Skin Inflammatory and Cancer Susceptibility Syndromes via Inflammasome Activation
Franklin L. Zhong,Ons Mamaï,Lorenzo Sborgi,Lobna Boussofara,Richard Hopkins,Kim S. Robinson,Ildikó Szeverényi,Takuya Takeichi,Takuya Takeichi,Reshmaa Balaji,Aristotle Lau,Hazel Tye,Hazel Tye,Keya Roy,Carine Bonnard,Patricia J. Ahl,L. A. Jones,Paul J. Baker,Paul J. Baker,Lukáš Lacina,Atsushi Otsuka,Pierre Fournié,François Malecaze,E. Birgitte Lane,Masashi Akiyama,Kenji Kabashima,Kenji Kabashima,John E. Connolly,Seth L. Masters,Seth L. Masters,Vincent Soler,Salma Samir Omar,John A. McGrath,Roxana Ioana Nedelcu,Moez Gribaa,Mohamed Denguezli,Ali Saad,Sebastian Hiller,Bruno Reversade +38 more
TL;DR: It is found that germline mutations in the inflammasome sensor NLRP1 cause two overlapping skin disorders: multiple self-healing palmoplantar carcinoma (MSPC) and familial keratosis lichenoides chronica (FKLC) and the first genetic evidence linkingNLRP1 to skin inflammatory syndromes and skin cancer predisposition is provided.
Journal ArticleDOI
Tumor infiltrating lymphocytes: The regulator of melanoma evolution (Review)
Mihaela Antohe,Roxana Ioana Nedelcu,Luciana Nichita,Cristiana Popp,Mirela Cioplea,Alice Brinzea,Anastasia Hodorogea,Andreea Calinescu,Mihaela Balaban,Daniela Adriana Ion,Carmen C. Diaconu,Coralia Bleotu,Daniel Pirici,Sabina Zurac,Gabriela Turcu +14 more
TL;DR: Current state of knowledge in the field of immune cells that infiltrate melanoma is discussed, resuming the potential of TIL components to become prognostic markers for natural evolution, for response to drugs or valuable targets for new medication.
Journal ArticleDOI
Variations in the expression of TIMP1, TIMP2 and TIMP3 in cutaneous melanoma with regression and their possible function as prognostic predictors.
Sabina Zurac,Monica Neagu,Carolina Constantin,Mirela Cioplea,Roxana Ioana Nedelcu,Alexandra Bastian,Cristiana Popp,Luciana Nichita,R Andrei,Tiberiu Tebeica,Cristiana Tanase,Virginia Chitu,Constantin Caruntu,Mihaela Ghita,Catalin M. Popescu,Daniel Boda,Bogdan Mastalier,Nicoleta Măru,Daha C,Bogdan Andreescu,Ioan Marinescu,Adrian Rebosapca,Florica Stăniceanu,Gabriela Negroiu,Daniela Adriana Ion,Dragana Nikitovic,George N. Tzanakakis,Demetrios A. Spandidos,Aristidis Tsatsakis +28 more
TL;DR: Findings on the differential expression of TIMP1, TIMP2 and TIMP3 in melanomas with regression support the hypothesis that the morphological differences identified in the melanoma regression spectrum may have a correlation with prognosis.
Journal ArticleDOI
Epithelial-Mesenchymal Transition in Skin Cancers: A Review.
Anastasia Hodorogea,Andreea Calinescu,Mihaela Antohe,Mihaela Balaban,Roxana Ioana Nedelcu,Gabriela Turcu,Daniela Adriana Ion,Ioana Anca Badarau,Catalin M. Popescu,Raluca Popescu,Cristiana Popp,Mirela Cioplea,Luciana Nichita,Ionela Hulea,Alice Brinzea +14 more
TL;DR: The purpose of this review is to determine particularities of the EMT process in the most common malignant cutaneous tumors (squamous cell carcinomas, basal cell carcinoma, and melanoma) which still have an increasingly high incidence.
Journal ArticleDOI
On the Dual Role of Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (CEACAM1) in Human Malignancies.
Andreea Calinescu,Gabriela Turcu,Roxana Ioana Nedelcu,Alice Brinzea,Anastasia Hodorogea,Mihaela Antohe,Carmen C. Diaconu,Coralia Bleotu,Daniel Pirici,Lucia B. Jilaveanu,Daniela Adriana Ion,Ioana Anca Badarau +11 more
TL;DR: The literature was reviewed and the various expression patterns of CEACAM1 in different types of tumors were discussed, describing its structure and general biologic functions and emphasizing the most significant findings that link this molecule to poor prognosis.