R
Roxane Tussiwand
Researcher at Washington University in St. Louis
Publications - 37
Citations - 4759
Roxane Tussiwand is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Immune system & Dendritic cell. The author has an hindex of 26, co-authored 29 publications receiving 3969 citations. Previous affiliations of Roxane Tussiwand include University of Washington & University of Basel.
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Journal ArticleDOI
Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny
Martin Guilliams,Florent Ginhoux,Claudia Jakubzick,Shalin H. Naik,Nobuyuki Onai,Barbara U. Schraml,Elodie Segura,Roxane Tussiwand,Simon Yona +8 more
TL;DR: This Opinion article suggests that the mononuclear phagocyte system can be classified primarily by their ontogeny and secondarily by their location, function and phenotype, which permits a more robust classification during both steady-state and inflammatory conditions.
Journal ArticleDOI
Transcriptional Control of Dendritic Cell Development
Theresa L. Murphy,Gary E. Grajales-Reyes,Xiaodi Wu,Roxane Tussiwand,Carlos G. Briseño,Arifumi Iwata,Nicole M. Kretzer,Vivek Durai,Kenneth M. Murphy +8 more
TL;DR: This work has assigned several nonredundant in vivo functions to distinct DC lineages, consisting of plasmacytoid DCs and several subsets of classical DCs that promote different immune effector modules in response to pathogens.
Journal ArticleDOI
Compensatory dendritic cell development mediated by BATF–IRF interactions
Roxane Tussiwand,Wan-Ling Lee,Theresa L. Murphy,Mona Mashayekhi,Wumesh Kc,Jörn C. Albring,Ansuman T. Satpathy,Jeffrey A. Rotondo,Brian T. Edelson,Nicole M. Kretzer,Xiaodi Wu,Leslie A. Weiss,Elke Glasmacher,Peng Li,Wei Liao,Michael S. Behnke,Samuel S. K. Lam,Cora T. Aurthur,Warren J. Leonard,Harinder Singh,Christina L. Stallings,L. David Sibley,Robert D. Schreiber,Kenneth M. Murphy +23 more
TL;DR: An alternative, Batf3-independent pathway in mice for CD8α+ dendritic cell development operating during infection with intracellular pathogens and mediated by the cytokines interleukin (IL)-12 and interferon-γ is identified.
Journal ArticleDOI
Klf4 Expression in Conventional Dendritic Cells Is Required for T Helper 2 Cell Responses
Roxane Tussiwand,Roxane Tussiwand,Bart Everts,Gary E. Grajales-Reyes,Nicole M. Kretzer,Arifumi Iwata,Juhi Bagaitkar,Xiaodi Wu,Rachel O.L. Wong,David A. Anderson,Theresa L. Murphy,Edward J. Pearce,Kenneth M. Murphy +12 more
TL;DR: Evidence is provided that Kruppel-like factor 4 (Klf4) is required in IRF4-expressing cDCs to promote Th2, but not Th17, cell responses in vivo.
Journal ArticleDOI
Specificity through cooperation: BATF-IRF interactions control immune-regulatory networks
TL;DR: The capacity of the BATF leucine zipper regions to mediate dimerization with AP-1 factors and also to define cooperative interactions with heterologous factors explains both the positive transcriptional activity of BATF proteins and how they activate distinct sets of target genes compared with FOS.