Author
Rubén A. Toscano
Other affiliations: Moscow State University, University of Göttingen, Ben-Gurion University of the Negev ...read more
Bio: Rubén A. Toscano is an academic researcher from National Autonomous University of Mexico. The author has contributed to research in topics: Crystal structure & Hydrogen bond. The author has an hindex of 31, co-authored 492 publications receiving 5456 citations. Previous affiliations of Rubén A. Toscano include Moscow State University & University of Göttingen.
Topics: Crystal structure, Hydrogen bond, Denticity, Chemistry, Schiff base
Papers published on a yearly basis
Papers
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TL;DR: In this article, three structural forms have been isolated among four 2-formyl- and 2-acetylpyridine N(4)-substituted thiosemicarbazones reported.
164 citations
TL;DR: Although the coupled products are obtained in excellent and in many cases nearly quantitative yields, the thiolation of iodobenzene with a broad scope of disulfides in the presence of zinc is inefficient.
156 citations
TL;DR: In this paper, 2-benzoylpyridine 4 N-substituted thiosemicarbazones and their copper(II) complexes were used for growth inhibition studies against two human pathogenic fungi.
106 citations
TL;DR: The (-)-S isomer of 5-benzoyl-1, 2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid is about 60 times more potent than the (+)-R isomer in the carrageenan edema test and 230 times more active in the mouse phenylquinone writhing assay.
Abstract: The (-)-S isomer of 5-benzoyl-1,2-dihydro-3H-pyrrolo[1,2-alpha]pyrrole-1-carboxylic acid is about 60 times more potent than the (+)-R isomer in the carrageenan edema test and ca. 230 times more active than the (+)-R isomer in the mouse phenylquinone writhing assay.
92 citations
TL;DR: In this paper, the crystal and molecular structures of nine ortho-hydroxy Schiff base ligands were determined by chemical analysis, mass spectrometry, 1H and 13C NMR spectroscopy.
91 citations
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TL;DR: New methods for the synthesis of complexes with N-heterocyclic carbene ligands such as the oxidative addition or the metal atom template controlled cyclized isocyanides have been developed recently.
Abstract: The chemistry of heterocyclic carbenes has experienced a rapid development over the last years. In addition to the imidazolin-2-ylidenes, a large number of cyclic diaminocarbenes with different ring sizes have been described. Aside from diaminocarbenes, P-heterocyclic carbenes, and derivatives with only one, or even no heteroatom within the carbene ring are known. New methods for the synthesis of complexes with N-heterocyclic carbene ligands such as the oxidative addition or the metal atom template controlled cyclization of β-functionalized isocyanides have been developed recently. This review summarizes the new developments regarding the synthesis of N-heterocyclic carbenes and their metal complexes.
2,454 citations
1,326 citations
1,256 citations
TL;DR: This review describes a multidimensional treatment of molecular recognition phenomena involving aromatic rings in chemical and biological systems that facilitates the development of new advanced materials and supramolecular systems, and should inspire further utilization of interactions with aromatic rings to control the stereochemical outcome of synthetic transformations.
Abstract: This review describes a multidimensional treatment of molecular recognition phenomena involving aromatic rings in chemical and biological systems. It summarizes new results reported since the appearance of an earlier review in 2003 in host-guest chemistry, biological affinity assays and biostructural analysis, data base mining in the Cambridge Structural Database (CSD) and the Protein Data Bank (PDB), and advanced computational studies. Topics addressed are arene-arene, perfluoroarene-arene, S⋅⋅⋅aromatic, cation-π, and anion-π interactions, as well as hydrogen bonding to π systems. The generated knowledge benefits, in particular, structure-based hit-to-lead development and lead optimization both in the pharmaceutical and in the crop protection industry. It equally facilitates the development of new advanced materials and supramolecular systems, and should inspire further utilization of interactions with aromatic rings to control the stereochemical outcome of synthetic transformations.
1,221 citations