R
Rubén Torres
Researcher at Spanish National Research Council
Publications - 18
Citations - 199
Rubén Torres is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Holliday junction & DNA repair. The author has an hindex of 7, co-authored 16 publications receiving 132 citations.
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Journal ArticleDOI
Bacillus subtilis DisA helps to circumvent replicative stress during spore revival.
Marina Raguse,Rubén Torres,Elena M. Seco,Carolina Gándara,Silvia Ayora,Ralf Moeller,Juan C. Alonso +6 more
TL;DR: It is proposed that DisA is necessary to coordinate responses to replicative stress; it could help to circumvent damaged template bases that otherwise impede fork progression.
Journal ArticleDOI
Bacillus Subtilis DisA Regulates RecA-mediated DNA Strand Exchange
Rubén Torres,Begoña Carrasco,Carolina Gándara,Amit K. Baidya,Sigal Ben-Yehuda,Juan C. Alonso +5 more
TL;DR: It is proposed that DisA may preserve genome integrity by downregulating RecA activities at several steps of the DNA damage tolerance pathway, allowing time for the repair machineries to restore genome stability.
Dynamics of DNA double-strand break repair in Bacillus subtilis
Begoña Carrasco,Paula P. Cárdenas,Ester Serrano,Rubén Torres,Elena M. Seco,Silvia Ayora,Juan C. Alonso +6 more
TL;DR: In this article, the damage-induced multi-protein complex (recombinosome), organized into focal assemblies, has been confirmed by biochemical approaches and analyzed the requirements of exponentially growing Bacillus subtilis cells.
Journal ArticleDOI
Activity and in vivo dynamics of Bacillus subtilis DisA are affected by RadA/Sms and by Holliday junction-processing proteins.
Carolina Gándara,Daniella Lucena,Rubén Torres,Ester Serrano,Stephan Altenburger,Peter L. Graumann,Juan C. Alonso +6 more
TL;DR: The data suggest a model in which DisA moving along dsDNA indicates absence of DNA damage/replication stress via normal c-di-AMP levels, while interaction with HJ DNA/halted forks leads to reduced c- DiAMP levels and an ensuing block in cell proliferation.
Journal ArticleDOI
Bacillus subtilis RadA/Sms contributes to chromosomal transformation and DNA repair in concert with RecA and circumvents replicative stress in concert with DisA.
TL;DR: It is proposed that RadA/Sms has two activities: to modulate DisA and to promote RecA-mediated DNA strand exchange, required to coordinate responses to replicative stress and genetic recombination.