R
Rui Hao
Researcher at Duke University
Publications - 12
Citations - 1342
Rui Hao is an academic researcher from Duke University. The author has contributed to research in topics: Ubiquitin ligase & Deubiquitinating enzyme. The author has an hindex of 11, co-authored 12 publications receiving 1111 citations. Previous affiliations of Rui Hao include University of California, Los Angeles & Chinese Academy of Sciences.
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Journal ArticleDOI
Target identification using drug affinity responsive target stability (DARTS)
Brett Lomenick,Rui Hao,Nao Jonai,Randall Chin,Mariam Aghajan,Sarah Warburton,Jianing Wang,Raymond Wu,Fernando Gomez,Joseph A. Loo,James A. Wohlschlegel,Thomas M. Vondriska,Jerry Pelletier,Harvey R. Herschman,Jon Clardy,Catherine F. Clarke,Jing Huang +16 more
TL;DR: In this paper, drug affinity responsive target stability (DARTS) is proposed to identify known small-molecule-protein interactions and reveal the eukaryotic translation initiation machinery as a molecular target for the longevity enhancing plant natural product resveratrol.
Journal ArticleDOI
Proteasomes Activate Aggresome Disassembly and Clearance by Producing Unanchored Ubiquitin Chains
Rui Hao,Priyaanka Nanduri,Yanhua Rao,R. Scott Panichelli,Akihiro Ito,Minoru Yoshida,Tso-Pang Yao +6 more
TL;DR: Unanchored ubiquitin chains are key signaling molecules that connect and coordinate the proteasome and autophagy to eliminate toxic protein aggregates.
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Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase.
Mariam Aghajan,Nao Jonai,Karin Flick,Fei Fu,Manlin Luo,Xiaolu Cai,Ikram Ouni,Nathan W. Pierce,Xiaobo Tang,Brett Lomenick,Robert Damoiseaux,Rui Hao,Pierre-Marie Del Moral,Rati Verma,Ying Li,Cheng Li,Kendall N. Houk,Michael E. Jung,Ning Zheng,Lan Huang,Raymond J. Deshaies,Peter K. Kaiser,Jing Huang +22 more
TL;DR: It is demonstrated that SMER3 diminishes binding of the F-box subunit Met30 to the SCF core complex in vivo and in vitro, and there is no fundamental barrier to obtaining specific inhibitors to modulate function of individual SCF complexes.
Journal ArticleDOI
Microtubule acetylation amplifies p38 kinase signalling and anti-inflammatory IL-10 production
Bin Wang,Yanhua Rao,Makoto Inoue,Rui Hao,Chun Hsiang Lai,David J. Chen,Stacey L. McDonald,Moon Chang Choi,Qiu Wang,Mari L. Shinohara,Tso-Pang Yao +10 more
TL;DR: It is reported that macrophages challenged by bacterial lipopolysaccharides (LPS) undergo extensive microtubule acetylation, identified as a kinase signaling modulator and a key component in the inflammatory response.
Journal ArticleDOI
Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling.
Kristi L. Norris,Rui Hao,Liang-Fu Chen,Chun-Hsiang Lai,Meghan Kapur,Peter J. Shaughnessy,Dennis Chou,Jin Yan,J. Paul Taylor,Simone Engelender,Anna E. West,Kah-Leong Lim,Tso-Pang Yao +12 more
TL;DR: Under moderate mitochondrial stress conditions, parkin stimulates mitochondrial fusion instead of mitophagy by catalyzing K63-linked ubiquitination and inactivating α-synuclein, which provides a physiological context to functionally connect key PARK genes in the pathogenesis of Parkinson disease.