R
Runze Gao
Researcher at Chinese Academy of Sciences
Publications - 5
Citations - 92
Runze Gao is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Mutation (genetic algorithm) & Genome. The author has an hindex of 2, co-authored 5 publications receiving 24 citations. Previous affiliations of Runze Gao include ShanghaiTech University.
Papers
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Journal ArticleDOI
Eliminating base-editor-induced genome-wide and transcriptome-wide off-target mutations.
Lijie Wang,Wei Xue,Hongxia Zhang,Runze Gao,Houyuan Qiu,Jia Wei,Lina Zhou,Yun-Ni Lei,Yun-Ni Lei,Xiaocheng Wu,Xiao Li,Chengfang Liu,Jing Wu,Qiubing Chen,Hanhui Ma,Xingxu Huang,Xingxu Huang,Cheguo Cai,Ying Zhang,Bei Yang,Hao Yin,Li Yang,Jia Chen,Jia Chen +23 more
TL;DR: In this article, the authors used a cleavable deoxycytidine deaminase inhibitor (dCDI) domain to construct a transformer base editors (tBE) system that induces efficient editing with only background levels of genome-wide and transcriptome-wide OT mutations.
Posted ContentDOI
Protocol for examining and eliminating base editor-induced genome-wide and transcriptome-wide off-target mutations
Lijie Wang,Wei Xue,Hongxia Zhang,Runze Gao,Houyuan Qiu,Jia Wei,Lina Zhou,Yun-Ni Lei,Xiaocheng Wu,Xiao Li,Chengfang Liu,Jing Wu,Qiubing Chen,Hanhui Ma,Xingxu Huang,Cheguo Cai,Ying Zhang,Bei Yang,Hao Yin,Li Yang,Jia Chen +20 more
TL;DR: A cleavable deoxycytidine deaminase inhibitor (dCDI) domain is applied to construct a transformer BE system that induces efficient editing with only background levels of genome-wide and transcriptome-wide OT mutations.
Journal ArticleDOI
Comparison of cytosine base editors and development of the BEable-GPS database for targeting pathogenic SNVs
Ying Wang,Runze Gao,Runze Gao,Jing Wu,Yi-Chun Xiong,Jia Wei,Sipin Zhang,Bei Yang,Jia Chen,Jia Chen,Li Yang,Li Yang +11 more
TL;DR: The in vivo comparison and in silico profiling catalog the availability of base editors and their broad applications in biomedical studies and builds the BEable-GPS database for users to select proper base editors to model or correct disease-related mutations.
Posted ContentDOI
No observable guide-RNA-independent off-target mutation induced by prime editor
Runze Gao,Zhi-Can Fu,Xiangyang Li,Ying Wang,Jia Wei,Guangye Li,Lijie Wang,Jing Wu,Wei Xue,Xingxu Huang,Xingxu Huang,Li Yang,Jia Chen,Jia Chen +13 more
TL;DR: This paper used whole-genome and whole-transcriptome sequencing to determine gRNA-independent off-target mutations in cells expanded from single colonies, in which PE generated precise editing at on-target sites.
Posted ContentDOI
A marine bacterial community that degrades poly(ethylene terephthalate) and polyethylene
Runze Gao,Congting Sun +1 more
TL;DR: This study establishes a stable and effective marine bacterial community for PET and PE degradation and sheds light on the degradation pathways and associated mechanistic processes, which paves a way to develop a microbial inoculant against plastic wastes.