R
Russell S. Whelan
Researcher at Yeshiva University
Publications - 9
Citations - 1364
Russell S. Whelan is an academic researcher from Yeshiva University. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 6, co-authored 9 publications receiving 1228 citations. Previous affiliations of Russell S. Whelan include Albert Einstein College of Medicine.
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Journal ArticleDOI
Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance
TL;DR: Pharmacological and genetic inhibition of apoptosis and necrosis lessens infarct size and improves cardiac function in these disorders and a better understanding of these processes and their interrelationships may allow for the development of novel therapies for the major heart syndromes.
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Mechanisms of Cell Death in Heart Disease
TL;DR: The possibility is raised that small molecules aimed at inhibiting cell death may provide novel therapies for these common and lethal heart syndromes.
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Bax regulates primary necrosis through mitochondrial dynamics
Russell S. Whelan,Klitos Konstantinidis,An-Chi Wei,Yun Chen,Denis E. Reyna,Saurabh Jha,Ying Yang,John W. Calvert,Tullia Lindsten,Craig B. Thompson,Michael T. Crow,Evripidis Gavathiotis,Gerald W. Dorn,Brian O'Rourke,Richard N. Kitsis +14 more
TL;DR: Bax and Bak play wider roles in cell death than previously appreciated and may be optimal therapeutic targets for diseases that involve both forms of cell death.
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Regulation of p53 tetramerization and nuclear export by ARC
Roger Foo,Roger Foo,Young-Jae Nam,Marc Jason Ostreicher,Mark D. Metzl,Russell S. Whelan,Chang Fu Peng,Anthony W. Ashton,Weimin Fu,Kartik Mani,Suet-Feung Chin,Elena Provenzano,Ian O. Ellis,Nichola Figg,Sarah E Pinder,Martin R. Bennett,Carlos Caldas,Richard N. Kitsis +17 more
TL;DR: It is concluded that nuclear ARC is induced in cancer cells and negatively regulates p53, which is almost always WT in primary human breast cancers with nuclear ARC.
Journal ArticleDOI
Cardiomyocyte Life-Death Decisions in Response to Chronic β-Adrenergic Signaling
Russell S. Whelan,Klitos Konstantinidis,Klitos Konstantinidis,Rui-Ping Xiao,Richard N. Kitsis +4 more
TL;DR: Mechanisms that mediate β-adrenergic–induced cell death are investigated and, in doing so, a survival pathway of potential clinical relevance is uncovered and is uncovered in this issue of Circulation Research.