R
Ruth Tal-Singer
Researcher at GlaxoSmithKline
Publications - 253
Citations - 19033
Ruth Tal-Singer is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: COPD & Spirometry. The author has an hindex of 60, co-authored 233 publications receiving 15827 citations. Previous affiliations of Ruth Tal-Singer include RAND Corporation & University of Pennsylvania.
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Journal ArticleDOI
Susceptibility to Exacerbation in Chronic Obstructive Pulmonary Disease
John R. Hurst,Jørgen Vestbo,Jørgen Vestbo,Antonio Anzueto,Nicholas Locantore,Hana Müllerová,Ruth Tal-Singer,Bruce E. Miller,David A. Lomas,Alvar Agusti,William MacNee,Peter M.A. Calverley,Stephen I. Rennard,Emiel F.M. Wouters,Jadwiga A. Wedzicha +14 more
TL;DR: Although exacerbations become more frequent and more severe as COPD progresses, the rate at which they occur appears to reflect an independent susceptibility phenotype, which has implications for the targeting of exacerbation-prevention strategies across the spectrum of disease severity.
Journal ArticleDOI
Characterisation of COPD heterogeneity in the ECLIPSE cohort
Alvar Agusti,Peter M.A. Calverley,Bartolome R. Celli,Harvey O. Coxson,Lisa D. Edwards,David A. Lomas,William MacNee,Bruce E. Miller,S.I. Rennard,Edwin K. Silverman,Ruth Tal-Singer,Emiel F.M. Wouters,Julie C. Yates,Jørgen Vestbo +13 more
TL;DR: The clinical manifestations of COPD are highly variable and the degree of airflow limitation does not capture the heterogeneity of the disease.
Journal ArticleDOI
Changes in forced expiratory volume in 1 second over time in copd
Jørgen Vestbo,Jørgen Vestbo,Lisa D. Edwards,Paul D. Scanlon,Julie C. Yates,Alvar Agusti,Per Bakke,Peter M.A. Calverley,Bartolome R. Celli,Harvey O. Coxson,Courtney Crim,David A. Lomas,William MacNee,Bruce E. Miller,Edwin K. Silverman,Ruth Tal-Singer,Emiel F.M. Wouters,Stephen I. Rennard +17 more
TL;DR: The rate of change in FEV(1) among patients with COPD is highly variable, with increased rates of decline among current smokers, patients with bronchodilator reversibility, and patients with emphysema.
Journal ArticleDOI
Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype.
Alvar Agusti,Lisa D. Edwards,Stephen I. Rennard,William MacNee,Ruth Tal-Singer,Bruce E. Miller,Jørgen Vestbo,Jørgen Vestbo,David A. Lomas,Peter M.A. Calverley,Emiel F.M. Wouters,Courtney Crim,Julie C. Yates,Edwin K. Silverman,Harvey O. Coxson,Per Bakke,Ruth J. Mayer,Bartolome R. Celli +17 more
TL;DR: Overall, the results identify a novel systemic inflammatory COPD phenotype that may be the target of specific research and treatment and show associations but do not prove causality.
Journal ArticleDOI
Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE).
Jørgen Vestbo,W. H. Anderson,Harvey O. Coxson,Courtney Crim,F Dawber,Lisa D. Edwards,G Hagan,Katharine Knobil,David A. Lomas,William MacNee,Edwin K. Silverman,Ruth Tal-Singer,Eclipse Investigators +12 more
TL;DR: Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points is the largest study attempting to better describe the subtypes of chronic obstructive pulmonary disease, as well as defining predictive markers of its progression.