Ryan A. Frieler

TL;DR: It is shown that myeloid MR is an important control point in macrophage polarization and that the function of MR on myeloids cells likely represents a conserved ancestral MR function that is integrated in a transcriptional network with PPARgamma and glucocorticoid receptor.

TL;DR: It is now clear that intercellular signaling and communication between these cell types are critical in the pathophysiology of ventricular hypertrophy and remodeling, and there is still much to be revealed about the specific roles of these celltypes and their overall contribution to the hypertrophic response.

TL;DR: It is predicted that the cardioprotective effect of low-dose aspirin on COX-1 may be blunted when taken with coxibs, and administration of celecoxib to dogs interferes with the ability of a low dose of aspirin to inhibit AA-induced ex vivo platelet aggregation.

TL;DR: The data demonstrate that myeloid MR activation exacerbates stroke and identify myeloids MR as a critical target for MR antagonists, and indicate that MR activation has an important role in controlling immune cell function during the inflammatory response to stroke.

TL;DR: Bacteria in tumors are found to induce production of IL17, which promotes influx of intratumor B cells that promote tumor growth and progression in mice with inflammation-induced and sporadic colon tumors.