Ryan D. Larochelle

Bio: Ryan D. Larochelle is an academic researcher from University of Colorado Boulder. The author has contributed to research in topics: Transplantation. The author has co-authored 1 publications.

3D Printing in Eye Care.

Abstract: Three-dimensional printing enables precise modeling of anatomical structures and has been employed in a broad range of applications across medicine. Its earliest use in eye care included orbital models for training and surgical planning, which have subsequently enabled the design of custom-fit prostheses in oculoplastic surgery. It has evolved to include the production of surgical instruments, diagnostic tools, spectacles, and devices for delivery of drug and radiation therapy. During the COVID-19 pandemic, increased demand for personal protective equipment and supply chain shortages inspired many institutions to 3D-print their own eye protection. Cataract surgery, the most common procedure performed worldwide, may someday make use of custom-printed intraocular lenses. Perhaps its most alluring potential resides in the possibility of printing tissues at a cellular level to address unmet needs in the world of corneal and retinal diseases. Early models toward this end have shown promise for engineering tissues which, while not quite ready for transplantation, can serve as a useful model for in vitro disease and therapeutic research. As more institutions incorporate in-house or outsourced 3D printing for research models and clinical care, ethical and regulatory concerns will become a greater consideration. This report highlights the uses of 3D printing in eye care by subspecialty and clinical modality, with an aim to provide a useful entry point for anyone seeking to engage with the technology in their area of interest.

3D Print, Circularity, and Footprints

Abstract: 3D printing is part of the advanced technology that is beneficial in many areas such as construction, packaging, and medicine because it can create objects that can offer a better understanding of specific prototypes or models that you want to study. In addition, it also allows a smaller-scale production with lower costs for companies, so its use represents a comparative advantage and allows creating complex and more personalized designs to offer to its customers. In general, three-dimensional printing represents an efficient form of production that has a wide range of possibilities for its use. However, it is essential to know its impact at the environmental level to manage better and control its use. In the present work, we seek to know the relationship between circularity and three-dimensional impressions and the carbon footprint on the planet. Different sources and comparisons were made, and examples were proposed to explain and describe each previously proposed relationship to meet the research objective. The analysis results concluded that the impact was undoubtedly less than traditional production methods but that there is much room for improvement to reduce further the footprint left by 3D printing, such as a change in the use of materials. On the other hand, it is possible to achieve 3D prints that are circular and sustainable over time by making the necessary efforts. Additionally, the requirements for sustainable production through 3D printing must be not only feasible but also accessible to all to make a real change starting from the smallest companies and individuals that use this technology to the mass productions made by large companies.

Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye Diseases

Abstract: Chronic ocular diseases can seriously impact the eyes and could potentially result in blindness or serious vision loss. According to the most recent data from the WHO, there are more than 2 billion visually impaired people in the world. Therefore, it is pivotal to develop more sophisticated, long-acting drug delivery systems/devices to treat chronic eye conditions. This review covers several drug delivery nanocarriers that can control chronic eye disorders non-invasively. However, most of the developed nanocarriers are still in preclinical or clinical stages. Long-acting drug delivery systems, such as inserts and implants, constitute the majority of the clinically used methods for the treatment of chronic eye diseases due to their steady state release, persistent therapeutic activity, and ability to bypass most ocular barriers. However, implants are considered invasive drug delivery technologies, especially those that are nonbiodegradable. Furthermore, in vitro characterization approaches, although useful, are limited in mimicking or truly representing the in vivo environment. This review focuses on long-acting drug delivery systems (LADDS), particularly implantable drug delivery systems (IDDS), their formulation, methods of characterization, and clinical application for the treatment of eye diseases.

Aplicações da manufatura aditiva em oftalmologia

Abstract: RESUMO A manufatura aditiva, mais popularmente conhecida como impressão tridimensional, baseia-se no desenvolvimento de um objeto com a ajuda de um software de desenho assistido por computador seguido de sua impressão por meio da deposição de uma matéria-prima, camada por camada, para a construção do produto desejado. Existem vários tipos de técnicas de impressão tridimensional, e o tipo de processo de impressão escolhido depende da aplicação específica do objeto a ser desenvolvido, dos materiais a serem utilizados e da resolução [...]

Innovation Process for Optical Face Scanner Used to Customize 3D Printed Spectacles

Abstract: Many people for different reasons end up wearing glasses to correct their vision. From time immemorial, there has been an unquestionable ability to associate people with glasses. Designing the glasses according to the physiognomy of each person opens a new path for a completely new optical experience. The frames are designed to fit perfectly on the face, are comfortable on the nose, and are positioned at an optimal distance from the cheeks and eyelashes. Three-dimensional printing technology offers the possibility to customize any form of glasses at a low cost with average quality. In this type of technology, the printer receives a digitized model of the spectacle frame (usually in STL file format) that must meet the parameters related to the wearer’s anatomy. Therefore, this paper presents an innovative process, an optical method used to scan the wearer’s face to design a parameterized design of the spectacle frames. The procedure has a measurement phase for quantifying the anatomical features of the wearer’s face, a para-metric design phase of the glasses for adjusting the design parameters according to the anatomical characteristics, and a manufacturing phase in which the custom eyeglass frame will be manufactured using 3D printing technology. The aim of this study was to create an innovative process that could be tested as an educational 3D printing system that could be used by undergraduate students (studying under an optometry program), a process that would begin at optometric prescription stage and can be used in the educational laboratory of the Department of Mechatronics and Precision Mechanics from the Politehnica University of Bucharest. Using this method we obtained a custom spectacle frame that can be prototyped using 3D printing. The 3D-printed polylactic acid (PLA) frames are lightweight, flexible, durable, and the innovative photogrammetry process gives designers the ability to create custom designs that cannot be created with traditional manufacturing techniques.