Ryan Hicks

TL;DR: CSF/serum albumin ratio correlated with CSF neurofilament light in LAD, MIX, VaD, and other groups but not with AD biomarkers, which suggests that BBB leakage is common in dementias.

TL;DR: A novel computational platform called Rational InDel Meta-Analysis (RIMA) is presented that enables an in-depth comprehensive analysis of Cas9-induced genetic alterations, especially InDels mutations, and can be used to quantitate the contribution of classical microhomology-mediated end joining (c-MMEJ) pathway in the formation of mutations at Cas9 target sites.

TL;DR: The data suggest that coculture of iPSC‐derived endothelial cells promotes barrier formation on a functional and transcriptional level, and the information about gene expression changes in coculture can be used to further improve iPSCs‐derived BBB models through selective pathway manipulation.

TL;DR: Human induced pluripotent stem cell (hiPSC)-derived astroglia (NES-Astro) developed under defined conditions through long-term neuroepithelial-like stem (ltNES) cells and modulation of astrocyte biology using APOE-annotated compounds is assessed.

TL;DR: A humanized mouse model with liver-specific expression of human PCSK9 and a human-like hypercholesterolemia phenotype is described, and it is demonstrated that this mouse can be used to evaluate antibody and gene editing-based (genome and base editing) therapies to modulate the expression ofhuman PCSK 9 and reduce cholesterol levels.