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Author

Ryan P. Badman

Other affiliations: Syracuse University
Bio: Ryan P. Badman is an academic researcher from Cornell University. The author has contributed to research in topics: Export performance & Panel data. The author has an hindex of 8, co-authored 15 publications receiving 208 citations. Previous affiliations of Ryan P. Badman include Syracuse University.

Papers
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Journal ArticleDOI
TL;DR: In this article, a prototype particle tracking telescope was constructed using Timepix and Medipix ASIC hybrid pixel assemblies as the six sensing planes Each telescope plane consisted of one 14 cm2 assembly, providing a 256 ×256 array of 55μm square pixels The telescope achieved a pointing resolution of 24μm at the position of the device under test.
Abstract: A prototype particle tracking telescope was constructed using Timepix and Medipix ASIC hybrid pixel assemblies as the six sensing planes Each telescope plane consisted of one 14 cm2 assembly, providing a 256 ×256 array of 55μm square pixels The telescope achieved a pointing resolution of 24μm at the position of the device under test During a beam test in 2009 the telescope was used to evaluate in detail the performance of two Timepix hybrid pixel assemblies; a standard planar 300μm thick sensor, and 285μm thick double sided 3D sensor This paper describes a charge calibration study of the pixel devices, which allows the true charge to be extracted, and reports on measurements of the charge collection characteristics and Landau distributions The planar sensor achieved a best resolution of 40±01μm for angled tracks, and resolutions of between 44 and 11μm for perpendicular tracks, depending on the applied bias voltage The double sided 3D sensor, which has significantly less charge sharing, was found to have an optimal resolution of 90±01μm for angled tracks, and a resolution of 160±02μm for perpendicular tracks Based on these studies it is concluded that the Timepix ASIC shows an excellent performance when used as a device for charged particle tracking

73 citations

Journal ArticleDOI
17 Oct 2019-Cell
TL;DR: It is demonstrated that the intrinsic mechanical properties of chromatin play a fundamental role in dictating precatenane formation and regulating chromatin topology, and that topoisomerase II relaxation displays a strong preference for a single chromatin fiber over a braided fiber.

39 citations

Journal ArticleDOI
TL;DR: Progress in nanophotonic manipulation and measurement is highlighted, as well as the potential for implementing these on-chip functionalities in biological research and biomedical applications.
Abstract: Optical trapping is a powerful and widely used laboratory technique in the biological and materials sciences that enables rapid manipulation and measurement at the nanometer scale. However, expanding the analytical throughput of this technique beyond the serial capabilities of established single-trap microscope-based optical tweezers remains a current goal in the field. In recent years, advances in nanotechnology have been leveraged to create innovative optical trapping methods that increase the number of available optical traps and permit parallel manipulation and measurement of arrays of optically trapped targets. In particular, nanophotonic trapping holds significant promise for integration with other lab-on-a-chip technologies to yield compact, robust analytical devices. In this review, we highlight progress in nanophotonic manipulation and measurement, as well as the potential for implementing these on-chip functionalities in biological research and biomedical applications. For further resources related to this article, please visit the WIREs website.

34 citations

Journal ArticleDOI
TL;DR: In this paper, an analysis of experiments conducted in the laboratory to measure the efficiency of formation of molecular hydrogen on amorphous silicates, a realistic analogue of interstellar dust grains, is presented.

31 citations

Journal ArticleDOI
TL;DR: This new generation of nanophotonic Standing Wave Array Traps significantly advances the development of a high performance, low cost optical tweezers array laboratory on-chip by reducing device fabrication cost, minimizing trapping laser specimen heating, increasing trapping force, and implementing commonly used trapping techniques.
Abstract: The advent of nanophotonic evanescent field trapping and transport platforms has permitted increasingly complex single molecule and single cell studies on-chip. Here, we present the next generation of nanophotonic Standing Wave Array Traps (nSWATs) representing a streamlined CMOS fabrication process and compact biocompatible design. These devices utilize silicon nitride (Si3N4) waveguides, operate with a biofriendly 1064 nm laser, allow for several watts of input power with minimal absorption and heating, and are protected by an anticorrosive layer for sustained on-chip microelectronics in aqueous salt buffers. In addition, due to Si3N4’s negligible nonlinear effects, these devices can generate high stiffness traps while resolving subnanometer displacements for each trapped particle. In contrast to traditional table-top counterparts, the stiffness of each trap in an nSWAT device scales linearly with input power and is independent of the number of trapping centers. Through a unique integration of microcirc...

25 citations


Cited by
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01 Jan 1999
TL;DR: In this paper, the authors explore whether the world economy is breaking up into regional trading and currency blocs centred on the European Community, Japan and the United States, and conclude with an analysis of how trends in regional economic integration can be used as building blocks for a stronger multilateral system.
Abstract: This book explores whether the world economy is breaking up into regional trading and currency blocs centred on the European Community, Japan and the United States. Frankel uses trade, investment and financial data to assess this issue. He concludes with an analysis of how trends in regional economic integration can be used as building blocks for a stronger multilateral system.

1,035 citations

Journal ArticleDOI
TL;DR: This review highlights the latest optical trapping configurations and their applications in bioscience, as well as recent advances down to the nanoscale, and discusses the future prospects of nanomanipulation.
Abstract: Since the invention of optical tweezers, optical manipulation has advanced significantly in scientific areas such as atomic physics, optics and biological science. Especially in the past decade, numerous optical beams and nanoscale devices have been proposed to mechanically act on nanoparticles in increasingly precise, stable and flexible ways. Both the linear and angular momenta of light can be exploited to produce optical tractor beams, tweezers and optical torque from the microscale to the nanoscale. Research on optical forces helps to reveal the nature of light-matter interactions and to resolve the fundamental aspects, which require an appropriate description of momenta and the forces on objects in matter. In this review, starting from basic theories and computational approaches, we highlight the latest optical trapping configurations and their applications in bioscience, as well as recent advances down to the nanoscale. Finally, we discuss the future prospects of nanomanipulation, which has considerable potential applications in a variety of scientific fields and everyday life.

424 citations

Journal ArticleDOI
TL;DR: In Spanish: Hacia Una Economia Mundial: sugerencias para una politica economica internacional, Series Biblioteca de Economia No.7, Orbis, Barcelona, 1985, 242 p. as mentioned in this paper
Abstract: textabstractIn Dutch: Naar een Nieuwe Wereldeconomie: voorstellen voor een internationaal economisch beleid, Rotterdam University Press, Rotterdam, 1965, XV + 335 p. In Spanish: Hacia Una Economia Mundial: sugerencias para una politica economica internacional, Series Biblioteca de Economia No.7, Orbis, Barcelona, 1985, 242 p.

294 citations

Journal ArticleDOI
25 Mar 2021
TL;DR: The physical principles of optical tweezers and the characteristics that make them a powerful tool to investigate single molecules are reviewed, followed by a survey of applications of these methods to the studies of protein-nucleic acid interactions, protein/RNA folding and molecular motors.
Abstract: Optical tweezers have become the method of choice in single-molecule manipulation studies. In this Primer, we first review the physical principles of optical tweezers and the characteristics that make them a powerful tool to investigate single molecules. We then introduce the modifications of the method to extend the measurement of forces and displacements to torques and angles, and to develop optical tweezers with single-molecule fluorescence detection capabilities. We discuss force and torque calibration of these instruments, their various modes of operation and most common experimental geometries. We describe the type of data obtained in each experimental design and their analyses. This description is followed by a survey of applications of these methods to the studies of protein–nucleic acid interactions, protein/RNA folding and molecular motors. We also discuss data reproducibility, the factors that lead to the data variability among different laboratories and the need to develop field standards. We cover the current limitations of the methods and possible ways to optimize instrument operation, data extraction and analysis, before suggesting likely areas of future growth. This Primer on optical tweezers describes the instrumentation and experimental designs used in most single-molecule optical tweezers assays and discusses optical tweezers measurements in systems of biophysical interest such as DNA elasticity, protein and RNA folding, and molecular motors.

174 citations