Ryan Z. Friedman

TL;DR: It is shown that TEs can contribute to regulatory plasticity by inducing redundancy and potentiating genetic drift locally while conserving genome architecture globally, revealing a paradigm for defining regulatory conservation in the noncoding genome beyond classic sequence-level conservation.

TL;DR: It is shown that transposable elements can contribute to regulatory plasticity by inducing redundancy and potentiating genetic drift locally while conserving genome architecture globally, revealing a paradigm for defining regulatory conservation in the noncoding genome beyond classic sequence-level conservation.

TL;DR: The first direct measurement of the effects of transformation on a fungal genome is provided by sequencing the genomes of 29 transformants and 30 untransformed controls with high coverage and shows that transformation of DNA segments flanked by long targeting sequences, followed by homologous recombination and selection for a drug marker, is extremely safe.

TL;DR: Friedman et al. as mentioned in this paper developed a new metric called information content, which captures the diverse combinations of different transcription binding sites that cis-regulatory sequences can have, and showed that it is possible to distinguish enhancers from silencers based on their information content.

TL;DR: Following publication of the original paper, an error was reported in the processing of Fig. 2 and the original article has been corrected and the publishers apologize for the error.