Author
Ryo Sato
Bio: Ryo Sato is an academic researcher from Osaka University. The author has contributed to research in topics: Cytochrome & Cytochrome b5. The author has an hindex of 47, co-authored 139 publications receiving 23616 citations.
Topics: Cytochrome, Cytochrome b5, Microsome, Reductase, Vesicle
Papers published on a yearly basis
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TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
11,895 citations
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
3,164 citations
740 citations
TL;DR: This chapter discusses enzymology and its applications in medicine, particularly in the field of regenerative medicine and its role in the treatment of cancer.
638 citations
National Institutes of Health1, University of North Carolina at Chapel Hill2, New York University3, University of Michigan4, University of Texas Southwestern Medical Center5, Vanderbilt University6, University of Illinois at Urbana–Champaign7, Scripps Research Institute8, Hoffmann-La Roche9, Queen Mary University of London10, Osaka University11
TL;DR: A modest revision of the initially proposed nomenclature of the P450 superfamily is described specifically for the human and mouse chromosomal loci, with the root symbol "CYP" for human ("Cyp" for mouse), denoting "cytochrome P450."
Abstract: In this update we provide a list of the 71 P450 genes and the four P450 pseudogenes that have been characterized as of September 30, 1988. The chromosomal locations of many of these genes are also summarized. A modest revision of the initially proposed nomenclature of the P450 superfamily (Nebert et al., DNA 6, 1–11, 1987) is described specifically for the human and mouse chromosomal loci. The motivation for this revision is to conform to the rules of nomenclature for human and mouse genes. Recommendations for the naming of chromosomal loci include the root symbol "CYP" for human ("Cyp" for mouse), denoting "cytochrome P450." We recommend that this root also be used for other organisms. For a chromosomal locus, the root symbol is followed by an Arabic numeral designating the P450 family, a letter indicating the sub-family, and an Arabic numeral representing the individual gene within the family or subfamily. Numbers of the individual genes usually will be assigned in the order the genes are ident...
586 citations
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TL;DR: Using this method, the liped peroxide level in the liver of rats suffering from carbon tetrachloride intoxication was investigated and was in good agreement with previously reported data obtained by measuring diene content.
24,847 citations
TL;DR: The present paper gives a detailed account of the investigations on rabbit liver microsomes and crude microsomal digests, which have led to postulate the hemoprotein nature of the pigment.
11,895 citations
TL;DR: It is demonstrated that the rat microtubule‐associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated to the autophagosome membranes after processing.
Abstract: Little is known about the protein constituents of autophagosome membranes in mammalian cells. Here we demonstrate that the rat microtubule-associated protein 1 light chain 3 (LC3), a homologue of Apg8p essential for autophagy in yeast, is associated to the autophagosome membranes after processing. Two forms of LC3, called LC3-I and -II, were produced post-translationally in various cells. LC3-I is cytosolic, whereas LC3-II is membrane bound. The autophagic vacuole fraction prepared from starved rat liver was enriched with LC3-II. Immunoelectron microscopy on LC3 revealed specific labelling of autophagosome membranes in addition to the cytoplasmic labelling. LC3-II was present both inside and outside of autophagosomes. Mutational analyses suggest that LC3-I is formed by the removal of the C-terminal 22 amino acids from newly synthesized LC3, followed by the conversion of a fraction of LC3-I into LC3-II. The amount of LC3-II is correlated with the extent of autophagosome formation. LC3-II is the first mammalian protein identified that specifically associates with autophagosome membranes.
6,244 citations
TL;DR: There is little doubt that measurements of bioaccumulation and biomarker responses in fish from contaminated sites offer great promises for providing information that can contribute to environmental monitoring programs designed for various aspects of ERA.
4,397 citations
TL;DR: This article corrects the article on p. 100 in vol.
Abstract: [This corrects the article on p. 100 in vol. 41.].
3,345 citations