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Ryosuke Ishimura
Researcher at Niigata University
Publications - 12
Citations - 1189
Ryosuke Ishimura is an academic researcher from Niigata University. The author has contributed to research in topics: Endoplasmic reticulum & Autophagy. The author has an hindex of 7, co-authored 10 publications receiving 909 citations. Previous affiliations of Ryosuke Ishimura include Juntendo University & Institute of Medical Science.
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Journal ArticleDOI
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Yoshinobu Ichimura,Satoshi Waguri,Yu-shin Sou,Shun Kageyama,Jun Hasegawa,Ryosuke Ishimura,Tetsuya Saito,Yinjie Yang,Tsuguka Kouno,Toshiaki Fukutomi,Takayuki Hoshii,Atsushi Hirao,Kenji Takagi,Tsunehiro Mizushima,Hozumi Motohashi,Myung-Shik Lee,Tamotsu Yoshimori,Keiji Tanaka,Masayuki Yamamoto,Masaaki Komatsu +19 more
TL;DR: It is shown that phosphorylation of the autophagy-adaptor protein p62 markedly increases p62's binding affinity for Keap1, an adaptor of the Cul3-ubiquitin E3 ligase complex responsible for degrading Nrf2, and that inhibitors of the interaction between phosphorylated p62 and Keap 1 have potential as therapeutic agents against human HCC.
Journal ArticleDOI
Proteasome Dysfunction Activates Autophagy and the Keap1-Nrf2 Pathway
Shun Kageyama,Shun Kageyama,Yu-shin Sou,Takefumi Uemura,Satoshi Kametaka,Tetsuya Saito,Tetsuya Saito,Ryosuke Ishimura,Ryosuke Ishimura,Tsuguka Kouno,Lynn Bedford,R. John Mayer,Myung-Shik Lee,Masayuki Yamamoto,Satoshi Waguri,Keiji Tanaka,Masaaki Komatsu,Masaaki Komatsu +17 more
TL;DR: In vivo data suggest that cells contain networks of cellular defense mechanisms against defective proteostasis, and both Nrf2 and autophagy serve as in vivo cellular adaptations to impaired proteasome.
Journal ArticleDOI
Dissection of the role of p62/Sqstm1 in activation of Nrf2 during xenophagy.
TL;DR: It is shown that translocation of p62/Sqstm1 to invasive Salmonella precedes Ser351 phosphorylation, which means that cytoprotective Nrf2 targets are induced at the same time that autophagosomes entrap the microbes (xenophagy).
Journal ArticleDOI
Biallelic Variants in UBA5 Link Dysfunctional UFM1 Ubiquitin-like Modifier Pathway to Severe Infantile-Onset Encephalopathy.
Mikko Muona,Ryosuke Ishimura,Ryosuke Ishimura,Anni Laari,Yoshinobu Ichimura,Tarja Linnankivi,Riikka Keski-Filppula,Riikka Keski-Filppula,Riitta Herva,Heikki Rantala,Heikki Rantala,Anders Paetau,Minna Pöyhönen,Miki Obata,Takefumi Uemura,Thomas Karhu,Norihisa Bizen,Hirohide Takebayashi,Shane McKee,Michael Parker,Nadia Akawi,Jeremy F. McRae,Matthew E. Hurles,Outi Kuismin,Outi Kuismin,Mitja I. Kurki,Anna-Kaisa Anttonen,Keiji Tanaka,Aarno Palotie,Satoshi Waguri,Anna-Elina Lehesjoki,Masaaki Komatsu +31 more
TL;DR: Exome sequencing in Finnish individuals with severe epileptic syndromes and cellular analyses imply that the combination of a hypomorphic p.Ala371Thr variant in trans with a loss-of-function allele in UBA5 underlies a severe infantile-onset encephalopathy, suggesting that the UFM1 system is essential for CNS development and function.
Journal ArticleDOI
Biallelic UFM1 and UFC1 mutations expand the essential role of ufmylation in brain development
Michael S. Nahorski,Sateesh Maddirevula,Ryosuke Ishimura,Saud Alsahli,Angela F. Brady,Anaïs Begemann,Tsunehiro Mizushima,Francisco J. Guzmán-Vega,Miki Obata,Yoshinobu Ichimura,Hessa S. Alsaif,Shams Anazi,Niema Ibrahim,Firdous Abdulwahab,Mais Hashem,Dorota Monies,Mohamed Abouelhoda,Brian F. Meyer,Majid Alfadhel,Wafa Eyaid,Markus Zweier,Katharina Steindl,Anita Rauch,Stefan T. Arold,C. Geoffrey Woods,Masaaki Komatsu,Fowzan S. Alkuraya,Fowzan S. Alkuraya +27 more
TL;DR: In this article, the authors established a locus for severe early-onset encephalopathy with progressive microcephaly based on two families, and map the phenotype to a novel homozygous UFM1 mutation.