S. Dasgupta

Bio: S. Dasgupta is an academic researcher from University of Calcutta. The author has contributed to research in topics: Serum albumin & Acid phosphatase. The author has an hindex of 2, co-authored 2 publications receiving 48 citations.

Role of plant metabolites in toxic liver injury.

Abstract: Aphanamixis polystachya is a traditional medicinal plant of the Meliaceae family in India. A crude ethanolic extract of the leaf of this plant shows a beneficial effect on toxic liver injury. Its antihepatotoxic activity was evaluated on carbon tetrachloride (CCl4)-induced liver injury in a rat model. The assessment of hepatoprotective activity was evaluated by measuring the activities of aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT), alkaline phosphatase (ALP), acid phosphatase (ACP) and lactate dehydrogenase (LDH), serum total bilirubin and albumin and histology of the liver. The crude leaf extract significantly inhibits the enhanced ASAT, ALAT, ALP, ACP and LDH activities released from the CCl4-intoxicated animals. It also ameliorated the depressed value of serum albumin and the enhanced value of total bilirubin in plasma caused by CCl4 intoxication. The study showed that the crude ethanolic extract from A. polystachya leaves provided protection against acute carbon tetrachloride-induced liver damage.

Hepatoprotective effect of amoora rohituka

Abstract: Antihepatotoxic activity of a resuspended residue of the alcohol extract of Amoora rohituka W & A. (Meliaceae) was studied in rats with hepatic injury induced by carbon tetrachloride. Carbon tetrachloride (1 ml/kg, i.p.) was administered twice a week for 3 weeks and an extract of A. rohituka (50 mg/kg/day) was given orally for the same period. The rats were sacrificed 24 h after the last CC14 challenge. Carbon tetrachloride induced elevations of alkaline phosphatase (ALP), glutamate pyruvate transaminase (CPT), alanine aminotransferase (ALAT), glutamate oxaloacetate transaminase (GOT), aspartate aminotransferase (ASAT) and lactate dehydrogenase (LDH) and total plasma bilirubin concentration as well as depression of total plasma cholesterol concentration were reduced significantly by the concurrent treatment of rats with A. rohituka suspension. Changes in the histological architecture of the liver produced by CC14 where also protected by the administration of A. rohituka suspension. These results i...

Central nervous system depressant and analgesic activity of Aphanamixis polystachya (Wall.) parker leaf extract in mice.

Abstract: In the present study, we have investigated the possible CNS (Central Nervous System) depressant and analgesic action of the methanol extract of Aphanamixis polystachya leaf. Its CNS depressant activity was evaluated by using thiopental sodium-induced sleeping time, hole cross and open field tests. The analgesic activity was also investigated for its central and peripheral pharmacological actions using hot plate and tail immersion test and acetic acid-induced writhing test in mice respectively. The extract decreased the motor activity and exploratory behavior of mice in hole cross and open field test (p < 0.001). Moreover, the extract significantly maximized the duration of sleeping time when administered with thiopental sodium (p < 0.001). The extract, at the dose of 250 and 500 mg/kg, produced a significant (p < 0.05, p < 0.001) increase in pain threshold both in hotplate and tail immersion methods in a dose dependent manner. The results were comparable to the reference standard Nalbuphine. In acetic acidinduced writhing test, the extract (500 mg/kg) produced a maximum of 75.9% inhibition (p < 0.001) of writhing reaction compared to the reference drug Diclofenac-Na (10 mg/kg) (78.1%). These results suggest that the extract possesses strong CNS depressant and analgesic activity in mice.