S. Dutta Gupta

TL;DR: Three different fractions of d -glucuronolactone dehydrogenase were isolated from rat liver supernatant by means of CM and DEAE Sephadex ion exchange chromatography, and enhanced activity was obtained with both substrates, but it varied in degree within the group of animals.

TL;DR: Microsomal fractions of tissues from various species that are known to produce l -ascorfoic acid—namely, amphibians, reptiles, mammals, and birds—were found to synthesize the vitamin from d -glucurono-1,4-lactone semicarbazone irrespective of whether the enzyme system is present in the kidney or in the liver.

TL;DR: In this article, the genetic basis for the loss of the ability to synthesize ascorbic acid in animals subject to scurvy was elucidating the genetic cause.

TL;DR: It has been indicated that the enhanced synthesis of l -ascorbic acid after administration of various drugs and toxic chemical compounds is due to the induced formation of this endogenous substrate.