S
S.G. Smith
Researcher at Cardiff University
Publications - 21
Citations - 403
S.G. Smith is an academic researcher from Cardiff University. The author has contributed to research in topics: Coproporphyrinogen Oxidase & Coproporphyrinogen III. The author has an hindex of 10, co-authored 21 publications receiving 401 citations.
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Journal ArticleDOI
Macrocyclic intermediates in the biosynthesis of porphyrins.
Anthony H. Jackson,Sancovich Ha,Ferramola Am,N. Evans,David E. Games,S. A. Matlin,George H. Elder,S.G. Smith +7 more
TL;DR: It is concluded that the decarboxylation of uroporphyrinogen III to coproporphrins III is a stepwise process taking place by a preferred pathway (both in normal and abnormal metabolism); the acetic acid groups are decar boxylated in a sequential clockwise fashion.
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The treatment of streptococcal infections in mice with 4:4'diaminodiphenylsulphone
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Synthetic and biosynthetic studies of porphyrins, part IV. Further studies of the conversion of coproporphyrinogen-III to protoporphyrin-IX: Mass spectrometric investigations of the incubation of specifically deuteriated coproporphyrinogen-III with chicken red cell haemolysates
TL;DR: High-performance liquid chromatography and field desorption mass spectrometry have provided evidence for the formation of a hydroxypropionic porphyrinogen as the primary intermediate in the conversion of coproporphyr inogen-III to harderoporphyrInogen.
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The porphyrins of normal human urine, with a comparison of the excretion pattern in porphyria cutanea tarda
TL;DR: The mode of action of uroporphyrin decarboxylase does not appear to be significantly different from normal in PCT, except in an overall deficiency in decar boxylation.
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Biosynthesis of protoporphyrin-IX from coproporphyrinogen-III
TL;DR: By use of tritium labelled substrates, and h.p.l.c., it is shown that protoporphyrin-IX (1d) is formed from coproporphyr inogen-IIIvia a specific pathway involving harderopomorphyrinogen (2b) rather than its isomer (2c).