S. Kirsch

TL;DR: The presence of not one but three spermatogenesis loci in Yq11 is proposed and that each locus is active during a different phase of male germ cell development.

TL;DR: A series of 30 DNA probes previously mapped to the long arm of the human Y chromosome is used to screen a panel of 21 patients with structural abnormalities in Yq, by genomic blot hybridisation, to localise microdeletions within interval 6, which it is believed may disrupt the azoospermia factor involved in spermatogenesis.

TL;DR: A rapid molecular screening programme has been established for the long arm of the human Y chromosome in Yq11 in order to quickly detect small interstitial deletions in this chromosome region indicative for deletion of AZF gene sequences.

TL;DR: The first results of this approach based on quantitative blot analysis of 51 DNA loci in 67 YAC clones revealed the presence of local amplification events of different DNA domains in distal Yq11.

TL;DR: First evidence that the human Y chromosome must have a function in spermatogenesis was given by Tiepolo and Zuffardi (1976) and the presence of a male fertility gene complex, called AZF, at the distal region of the euchromatic part of the long Y arm is confirmed.