S. M. Rafiqul Islam

TL;DR: NCYM, a cis-antisense gene of the MYCN oncogene, encodes a de novo evolved protein regulating the pathogenesis of human cancers, particularly neuroblastoma, and this work shows that NCYM is the first de noovo evolved protein known to act as an oncopromoting factor in human cancer, and suggest that de noVO evolved proteins may functionally characterize human disease.

TL;DR: A newly synthesized Nickel (II) tyrosine complex was screened as potential antimicrobial agent against a number of medically important bacteria and fungi and the values were found between 4~64 μg ml−1.

TL;DR: It is shown that MYCN and its cis‐antisense gene, NCYM, form a positive feedback loop with OCT4, a core regulatory gene maintaining a multipotent state of neural stem cells, which contributes to aggressiveness of MYCN‐amplified human neuroblastomas.

TL;DR: Results reveal a novel function of NCYM as a regulator of Myc-nick production in human neuroblastomas, and promote cleavage of MYCN to produce the anti-apoptotic protein, MyC-nick, both in vitro and in vivo.

TL;DR: The results suggest that SH‐IN 4F cells are partially reprogrammed NB cells, and could be a suitable model for investigating the plasticity of aggressive tumors.