S. MacKinnon

TL;DR: Extracts of 22 species of Meliaceae were examined for antimalarial activity using in vitro tests with two clones of Plasmodium falciparum, one sensitive tochloroquine (W2) and one chloroquine-resistant (D6), suggesting there is no cross-resistance to chloroquines.

TL;DR: Hirtin and various extracts from T. connaroides significantly reduced larval growth and consumption rates, as well as dietary utilization, indicating that these substances possess both behavioral effects and post-ingestive toxicity.

TL;DR: Gedunin has significant in vitro activity but initially showed poor in vivo activity, and the results show the potential for both antimalarial drug and phytomedicine development from traditionally used plants.

TL;DR: The antifeedant bioassay provides a rapid and inexpensive method for screening novel compounds available in small quantities to assess their activity as insect antifeingants.

TL;DR: It is suggested that chemical defenses are most important in areas of the tropics where soils are nutrient deficient (oligotrophic) and where loss of foliage to herbivory involves the loss of scarce plant macro- and micronutrients, which are more critical than replaceable carbohydrates.