S
S. Patel
Researcher at Merck & Co.
Publications - 29
Citations - 1974
S. Patel is an academic researcher from Merck & Co.. The author has contributed to research in topics: Receptor & Medicine. The author has an hindex of 15, co-authored 24 publications receiving 1868 citations.
Papers
More filters
Journal ArticleDOI
Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3
Wayne M. Geissler,Daphne L. Davis,Ling Wu,Karen D. Bradshaw,S. Patel,Berenice B. Mendonca,Keith O. Elliston,Jean D. Wilson,David W. Russell,Stefan Andersson +9 more
TL;DR: Four substitution and two splice junction mutations were identified in the 17βHSD3 genes of five unrelated male pseudohermaphrodites that severely compromised the activity of the 17 β–HSD type 3 isozyme.
Journal ArticleDOI
Simvastatin Has Anti-Inflammatory and Antiatherosclerotic Activities Independent of Plasma Cholesterol Lowering
Carl P. Sparrow,Charlotte Burton,Melba Hernandez,Steven S. Mundt,Heide Hassing,S. Patel,Ray Rosa,Anne Hermanowski-Vosatka,Pei-Ran Wang,Donghui Zhang,Larry Peterson,Patricia A. Detmers,Yu-Sheng Chao,Samuel D. Wright +13 more
TL;DR: It is confirmed that simvastatin is anti-inflammatory by using a classic model of inflammation: carrageenan-induced foot pad edema, which significantly reduced the extent of edema and was comparable to indomethacin in this model.
Journal ArticleDOI
Infectious Agents Are Not Necessary for Murine Atherogenesis
Samuel D. Wright,Charlotte Burton,Melba Hernandez,Heide Hassing,Judy Montenegro,Steve Mundt,S. Patel,Deborah Card,Anne Hermanowski-Vosatka,James D. Bergstrom,Carl P. Sparrow,Patricia A. Detmers,Yu-Sheng Chao +12 more
TL;DR: These studies show that infection is not necessary for murine Atherosclerosis and that, unlike peptic ulcer, Koch's postulates cannot be fulfilled for any infectious agent in atherosclerosis.
Journal ArticleDOI
Simvastatin has anti-inflammatory and anti-atherosclerotic activities independent of plasma cholesterol-lowering
Carl P. Sparrow,Charlotte Burton,Melba Hernandez,Steven S. Mundt,Heide Hassing,S. Patel,Ray Rosa,Anne Hermanowski-Vosatka,Pei-Ran Wang,Donghui Zhang,Larry Peterson,Patricia A. Detmers,Yu-Sheng Chao,Samuel D. Wright +13 more
TL;DR: It is confirmed that simvastatin is anti-inflammatory by using a classic model of inflammation: carrageenan-induced foot pad edema, and the hypothesis that simVastatin has antiatherosclerotic activity beyond its plasma cholesterol–lowering activity is supported.
Journal ArticleDOI
Schizophrenia and L-745, 870, a novel dopamine D4 receptor antagonist
TL;DR: Despite several lines of evidence which suggest that a selective D4 receptor antagonist may be an effective antipsychotic agent with a lower propensity to induce extrapyramidal side-effects, L-745,870 was ineffective as an antipsychotics in humans.