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S

S. Patel

Researcher at Merck & Co.

Publications -  29
Citations -  1974

S. Patel is an academic researcher from Merck & Co.. The author has contributed to research in topics: Receptor & Medicine. The author has an hindex of 15, co-authored 24 publications receiving 1868 citations.

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Male pseudohermaphroditism caused by mutations of testicular 17β-hydroxysteroid dehydrogenase 3

TL;DR: Four substitution and two splice junction mutations were identified in the 17βHSD3 genes of five unrelated male pseudohermaphrodites that severely compromised the activity of the 17 β–HSD type 3 isozyme.
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Simvastatin Has Anti-Inflammatory and Antiatherosclerotic Activities Independent of Plasma Cholesterol Lowering

TL;DR: It is confirmed that simvastatin is anti-inflammatory by using a classic model of inflammation: carrageenan-induced foot pad edema, which significantly reduced the extent of edema and was comparable to indomethacin in this model.
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Infectious Agents Are Not Necessary for Murine Atherogenesis

TL;DR: These studies show that infection is not necessary for murine Atherosclerosis and that, unlike peptic ulcer, Koch's postulates cannot be fulfilled for any infectious agent in atherosclerosis.
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Simvastatin has anti-inflammatory and anti-atherosclerotic activities independent of plasma cholesterol-lowering

TL;DR: It is confirmed that simvastatin is anti-inflammatory by using a classic model of inflammation: carrageenan-induced foot pad edema, and the hypothesis that simVastatin has antiatherosclerotic activity beyond its plasma cholesterol–lowering activity is supported.
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Schizophrenia and L-745, 870, a novel dopamine D4 receptor antagonist

TL;DR: Despite several lines of evidence which suggest that a selective D4 receptor antagonist may be an effective antipsychotic agent with a lower propensity to induce extrapyramidal side-effects, L-745,870 was ineffective as an antipsychotics in humans.