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S.R. Bhandari

Bio: S.R. Bhandari is an academic researcher. The author has contributed to research in topics: Catalysis & Chemistry. The author has an hindex of 1, co-authored 1 publications receiving 68 citations.

Papers
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Journal ArticleDOI
TL;DR: An amorphous phenanthrene, named nudol has been isolated from Eulophia nuda, Eria carinata and E. stricta and was identified as 2,7-dihydroxy-3,4-dimethoxyphenanthrene.

74 citations

Journal ArticleDOI
TL;DR: In this paper , the 3D structures of the enzyme Lathyrus aphaca Ribulose bisphosphate carboxylase (LArbcL) were modeled using homology modeling.
Abstract: In the current report, 3D structures of the enzyme Lathyrus aphaca Ribulose bisphosphate carboxylase (LArbcL) was modeled using homology modeling. The structures of the synthesized β-amino carbonyl derivatives were made by means of “Chem Draw ultra-12.0”, ADMET prediction were conducted to compute physicochemical properties. Pharmacokinetics studies and the molecular docking study of the synthesized compounds were performed against Lathyrus aphaca Ribulose bisphosphate carboxylase. Docking experiments verified a significant Docking Score values between 6.2 to 7.3 kcal mol−1. The highest-ranking complexes obtained from docking results were subjected to 100 ns Molecular Dynamics simulations using Gromacs program to investigate the constancy of the docked “protein–ligand complexes” as well as the oscillation and conformational variations that occur during protein–ligand interaction. The synthesized derivatives were screened for pre-emergence and post-emergence herbicidal activity adjacent to weed species named Lathyrus aphaca with concentrations of “0.005 M, 0.01 M and 0.02 M”, and the activity was compared with Butachlor and penoxulum which are standard herbicide. Every single synthesized compounds show good to moderate activity.

4 citations

Journal ArticleDOI
TL;DR: Triaryl-substituted pyridines have found extensive application in such fields as supra-molecular chemistry as mentioned in this paper , and exhibit antimalarial 2 , anticonvulsant 3 and antimicrobial 4 activities.
Abstract: Triaryl-substituted pyridines have found extensive application in such fields as supra-molecular chemistry. 1 They exhibit antimalarial 2 , anticonvulsant 3 and antimicrobial 4 activities. They are used in agrochemistry as fungicides, pesticides and herbicides. 5 Tri-substituted pyridines have been previously synthesized using CoCl 2. 6H 2 O 6 , TS-1 zeolite, 7 mesoporous organic polymer based on Calix, 8 Fe 3 O 4 @

Cited by
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TL;DR: The present study reviews the traditional therapeutic uses of orchidaceous preparations with its recent advances in pharmacological investigations that would be a useful reference for plant drug researches, especially in orchids.

287 citations

Journal ArticleDOI
TL;DR: The present study furnishes an overview of the hydroxy or/and methoxy-substituted 9,10-dihydro/phenanthrene, methylated, prenylated and other monomeric derivatives, dimeric and trimeric phenanthrenes and their biological activities.

282 citations

Journal ArticleDOI
TL;DR: Root amendments had a greater impact over time on phenanthrene degraders than heterotrophs resulting in selective maintenance of degrader populations in amended soils compared with controls.
Abstract: To investigate the mechanisms by which slender oat (Avena barbata Pott ex Link) enhances phenanthrene biodegradation, we analyzed the impacts of root exudates and root debris on phenanthrene biodegradation and degrader community dynamics. Accelerated phenanthrene biodegradation rates occurred in soils amended with slender oat root exudates as well as combined root debris + root exudate as compared with unamended controls. Root exudates significantly enhanced phenanthrene biodegradation in rhizosphere soils, either by increasing contaminant bioavailability and/or increasing microbial population size and activity. A modified most probable number (MPN) method was used to determine quantitative shifts in heterotrophic and phenanthrene degrader communities. During the first 4 to 6 d of treatment, heterotrophic populations increased in all amended soils. Both root debris-amended and exudate-amended soil then maintained larger phenanthrene degrader populations than in control soils later in the experiment after much of the phenanthrene had been utilized. Thus, root amendments had a greater impact over time on phenanthrene degraders than heterotrophs resulting in selective maintenance of degrader populations in amended soils compared with controls.

184 citations

Journal ArticleDOI
TL;DR: Two new phenanthrenes (4,9-dimethoxyphenanthrene-2,5-diol and 4,6-dimethyltoxymethylhexane-1,3,7-triol) and two new 9,10-dihydrophenanthreness (4methoxy-9, 10-dibenzyls and the triterpenoid friedelin were isolated and characterized from the hexane extract of the orchid Bulbophyllum vaginatum) were determined by spectroscopic analyses

94 citations

Journal ArticleDOI
TL;DR: Compounds 1-3 and denthyrsinin (1,5,7-trimethoxyphenanthrene-2,6-diol; 4) showed significant cytotoxic activities against Hela (13.5, 9.5 and 4.8 microM, respectively) cell lines.

79 citations