Author
S. Satyanarayana
Other affiliations: Andhra University
Bio: S. Satyanarayana is an academic researcher from Indian Institute of Chemical Technology. The author has contributed to research in topics: Catalysis & Hydroacylation. The author has an hindex of 4, co-authored 12 publications receiving 41 citations. Previous affiliations of S. Satyanarayana include Andhra University.
Topics: Catalysis, Hydroacylation, Bromide, Gliclazide, Mexiletine
Papers
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TL;DR: Microwave-induced cyclocondensation of methyl 2-(acetoxy(phenyl)methyl)acrylate with 2-aminopyridines under catalyst and solvent-free conditions has been achieved for a rapid synthesis of 3-substituted-2 H -pyrido[1,2- a ]pyrimidin-2-ones in good yields with high selectivity in short reaction times as discussed by the authors.
12 citations
TL;DR: In this article, an improved method was developed for the hydroacylation of enones with aldehydes employing bis-5-(2-hydroxyethyl)-1,3-thiazolium bromide/Et3N system to afford the corresponding 1,4-diketones in good yields.
9 citations
Journal Article•
TL;DR: The antigastric ulcer activity of agnitundirasa (20mg/kg) was found to be equal to the effect produced by cimetidine (20 mg/kg).
Abstract: Agnitundirasa was tested for antigastric ulcer activity in shay rat model. Oral dose of 10 mg/kg reduced the ulceration in shay rat. With 20mg/kg dose the ulceration was completely absent. The antigastric ulcer activity of agnitundirasa (20 mg/kg) was found to be equal to the effect produced by cimetidine (20 mg/kg). The reduction in gastric acidity was more with cimetidine and the reduction in peptic activity was more with agnitundirasa.
6 citations
Journal Article•
6 citations
TL;DR: In this article, a three-component coupling of indoles, aldehydes, and Nalkylanilines has been achieved using a catalytic amount of cellulose-sulfonic acid under mild reaction conditions to furnish the 3-a...
Abstract: Three-component coupling (3CC) of indoles, aldehydes, and N-alkylanilines has been accomplished using a catalytic amount of cellulose–sulfonic acid under mild reaction conditions to furnish the 3-a...
5 citations
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2,177 citations
TL;DR: The reaction is initiated by the photolysis of hypervalent iodine(III) reagents under mild, metal-free conditions, and is the first example of diastereoselective addition of acyl radicals to olefins to afford chiral ketones in a highly stereoselectives fashion.
Abstract: Diastereoselective radical hydroacylation of chiral alkylidenemalonates with aliphatic aldehydes is realized by the combination of a hypervalent iodine(III) reagent and UV-light irradiation. The reaction is initiated by the photolysis of hypervalent iodine(III) reagents under mild, metal-free conditions, and is the first example of diastereoselective addition of acyl radicals to olefins to afford chiral ketones in a highly stereoselective fashion. The obtained optically active ketones are useful chiral synthons, as exemplified by the short formal synthesis of (-)-methyleneolactocin.
34 citations
Journal Article•
TL;DR: The findings suggest that the significant gastroprotective activity of the aqueous extract of Hingwashtak churna could be mediated by its antioxidant activity which was evaluated by using different antioxidant models of screening.
Abstract: The aqueous extract of Hingwashtak churna was evaluated for gastroprotection in rats using the ibuprofen and ethanol induced ulcer models. Efficacy was assessed by determination of mean ulcer size, ulcer number and ulcer index. Oral administration of the aqueous extract (750 mg/kg) significantly protected against gastric lesions by 84.96% and 91.12% as compared to ranititidine (95.54 and 95.2%) in the ibuprofen and alcohol induced ulcer models respectively. The findings suggest that the significant gastroprotective activity could be mediated by its antioxidant activity which was evaluated by using different antioxidant models of screening.
32 citations
15 May 2018
25 citations
TL;DR: This review summarizes the recent (2000-2019) meaningful papers in which the in-depth study and exploitation of the aza-alkylation reaction at indole's C3 position is reported.
Abstract: The aza-alkylation reaction at indole's C3 position allows the introduction of a differently substituted aminomethyl group, with the formation of a new stereogenic centre. The reaction involves essentially three different partners: an indole, aldehyde and amine. The formation of the reactive iminium species can be catalyzed by metals, Bronsted acids, Lewis acids or organocatalysts. The stereoselective reaction is feasible with satisfactory outcomes. This review summarizes the recent (2000–2019) meaningful papers in which the in-depth study and exploitation of this reactivity are reported.
22 citations