S Sen

Bio: S Sen is an academic researcher. The author has contributed to research in topics: Coelogyne cristata. The author has an hindex of 2, co-authored 2 publications receiving 50 citations.

Orchids : A review of uses in traditional medicine, its phytochemistry and pharmacology

Abstract: Many of the epiphytic orchids are used as traditional medicine. Chemical components and pharmacology have been studied in recent 15 years. Medicinal orchids, in general, are not subjected to detailed pharmacological studies. A wide range of chemical compounds are presented including alkaloids, bibenzyl derivatives, flavonoids, phenanthrenes and terpenoids which have been isolated recently from this species. Extracts and metabolites of these plants, particularly those from flowers and leaves, possess useful pharmacological activities. Particular attention has been given to diuretic, anti-rheumatic, anti-inflammatory, anti-carcinogenic, hypoglycemic activities, antimicrobial, anticonvulsive, relaxation, neuroprotective, and antivirus, activities. A comprehensive account of chemical constituents and biological activities is presented and a critical appraisal of the ethnopharmacological issues is included in view of the many recent findings of importance of these orchids. A large number of orchids have been empirically used for treatment of different diseases, thus, several studies have been undertaken to provide scientific proof to justify the medicinal use of various plants in treatment of diseases. The aim of this review is to up-date and to present a comprehensive analysis of traditional and folklore uses, pharmacological reports and phyto-constituents isolated from the orchids family. Key words: Orchids, medicinal plant, traditional uses, chemical constituents, biological activities.

Antimicrobial Activity of Necklace Orchids is Phylogenetically Clustered and can be Predicted With a Biological Response Method.

Abstract: Necklace orchids (Coelogyninae, Epidendroideae) have been used in traditional medicine practices for centuries. Previous studies on a subset of unrelated orchid species utilized in these traditional practices revealed they possessed antimicrobial, anti-inflammatory, and anti-oxidant activity, providing experimental proof for their medicinal properties. To date however none of these species have been investigated ethno-botanically in a phylogenetic context. This study carried out comparative bioprospecting for a group of wild orchids using EBDCS (the Economic Botany Data Collection Standards) organ targeted and biological response methods. The traditional medicinal use of necklace orchids was recorded from books and journals published between 1984 and 2016. Two orchids, Coelogyne cristata and Coelogyne fimbriata, were selected, cultivated both indoors and outdoors, and the antimicrobial properties on extracts from their leaves and pseudobulbs tested against a selection of human pathogens. A molecular phylogeny of Coelogyninae based on nuclear ribosomal ITS and plastid matK DNA sequences obtained from 148 species was reconstructed with Maximum Likelihood (ML) using RAxML, Maximum Parsimony (MP) using PAUP and Bayesian Inference using MrBayes. Bioprospecting comparison of EBDCS and biological response was carried out using customized R scripts. Ethanolic extracts obtained from leaves of C. fimbriata inhibited growth of Bacillus cereus, Staphylococcus aureus, and Yersinia enterocolitica, confirming the antimicrobial properties of these extracts. Leaf extracts were found to have slightly stronger antimicrobial properties for plants cultivated outdoors than indoors. These differences were not found to be statistically significant though. Three hot nodes with high potency for antimicrobial activities were detected with the EBDCS organ targeted classification method, and eight hot nodes were detected with the biological response classification method. The biological response classification method is thus a more effective tool in finding hot nodes amongst clades of species with high medicinal potential.