Author
Saadia A. Tayel
Bio: Saadia A. Tayel is an academic researcher from Cairo University. The author has contributed to research in topics: Transdermal & Permeation. The author has an hindex of 10, co-authored 16 publications receiving 513 citations.
Topics: Transdermal, Permeation, Bioavailability, In vivo, Ex vivo
Papers
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TL;DR: F31 in situ NE gel showed the least ocular irritation potential and significantly (P<0.01) higher C(max, delayed T(max), prolonged mean residence time and increased bioavailability.
141 citations
TL;DR: The protection of male albino mice against the convulsion, induced by electroshock, was lower in case of liquisolid tablets compared to Tegretol suspension and tablets probably due to the precipitation of CBZ in the silica pores resulting from its high dose.
119 citations
TL;DR: It is proposed that topical ME formulation, containing higher fraction of oil solubilized drug, could be promising for sustained transdermal delivery of drug.
105 citations
TL;DR: The biodistribution study showed that the transdermal 99mTc-SF hydrogel exhibited a more sustained release pattern and longer circulation duration with pulsatile behavior in the blood and higher brain levels than the oral 99mRq-SF dispersion.
Abstract: Haloperidol (Hal) is one of the widely used antipsychotic drugs. When orally administered, it suffers from low bioavailability due to hepatic first pass metabolism. This study aimed at developing Hal-loaded penetration enhancer-containing spanlastics (PECSs) to increase transdermal permeation of Hal with sustained release. PECSs were successfully prepared using ethanol injection method showing reasonable values of percentage entrapment efficiency, particle size, polydispersity index and zeta potential. The statistical analysis of the ex vivo permeation parameters led to the choice of F1L – made of Span® 60 and Tween® 80 at the weight ratio of 4:1 along with 1% w/v Labrasol® – as the selected formula (SF). SF was formulated into a hydrogel by using 2.5% w/v of HPMC K4M. The hydrogel exhibited good in vitro characteristics. Also, it retained its physical and chemical stability for one month in the refrigerator. The radiolabeling of SF showed a maximum yield by mixing of 100 µl of diluted formula wit...
57 citations
TL;DR: Enteric surface-coated spanlastic dispersions as controlled-release duodenum-triggered systems able to surmount PVS drawbacks are developed and the higher Cmax, delayed Tmax, prolonged MRT, longer elimination t50% and enhanced oral bioavailability unravel E-S6 potential for oral PVS delivery.
53 citations
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855 citations
TL;DR: Over the past few decades, microbial polysaccharides have been under intense investigation due to their advantageous physicochemical properties, which led to the development of controlled release forms based on gellan.
265 citations
TL;DR: The use of buffers to maintain the pH within a desired range is a very common practice in chemical, biochemical and biological studies as discussed by the authors and their impact on biological systems is also presented.
Abstract: The use of buffers to maintain the pH within a desired range is a very common practice in chemical, biochemical and biological studies. Among them, zwitterionic N-substituted aminosulfonic acids, usually known as Good’s buffers, although widely used, can complex metals and interact with biological systems. The present work reviews, discusses and updates the metal complexation characteristics of thirty one commercially available buffers. In addition, their impact on biological systems is also presented. The influences of these buffers on the results obtained in biological, biochemical and environmental studies, with special focus on their interaction with metal ions, are highlighted and critically reviewed. Using chemical speciation simulations, based on the current knowledge of the metal–buffer stability constants, a proposal of the most adequate buffer to employ for a given metal ion is presented.
241 citations
TL;DR: It was found that liquisolid tablets formulated with Cremophor EL at drug concentration of 20%w/w produced high dissolution profile with acceptable tablet properties, and physicochemical interaction between naproxen and the excipients was investigated.
201 citations
TL;DR: This review covers the most well-known methods for assessing the cutaneous absorption of drugs as an auxiliary tool for pharmaceutical formulation scientists in the design of drug delivery systems.
Abstract: The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal formulations. In vitro and in vivo evaluations of these novel drug delivery systems are necessary to characterize their quality and efficacy. This review covers the most well-known methods for assessing the cutaneous absorption of drugs as an auxiliary tool for pharmaceutical formulation scientists in the design of drug delivery systems. In vitro methods as skin permeation assays using Franz-type diffusion cells, cutaneous retention and tape-stripping methods to study the cutaneous penetration of drugs, and in vivo evaluations as pre-clinical pharmacokinetic studies in animal models are discussed. Alternative approaches to cutaneous microdialysis are also covered. Recent advances in research on skin absorption of drugs and the effect of skin absorption enhancers, as investigated using confocal laser scanning microscopy, Raman confocal microscopy, and attenuated total reflectance Fourier-transform infrared spectroscopy, are reviewed.
190 citations