Saara Laitinen

TL;DR: The MISEV2018 guidelines include tables and outlines of suggested protocols and steps to follow to document specific EV-associated functional activities, and a checklist is provided with summaries of key points.

TL;DR: A comprehensive overview of the current understanding of the physiological roles of EVs is provided, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia.

TL;DR: In this paper, the authors summarize recent developments and the current knowledge of extracellular vesicles (EVs) and discuss safety and regulatory requirements that must be considered for pharmaceutical manufacturing and clinical application.

TL;DR: The data show that multiple changes in gene expression characterize simple steatosis, and genes involved in hepatic glucose and lipid metabolism, insulin signaling, inflammation, coagulation, and cell adhesion are found to be significantly associated with liver fat content.

TL;DR: An EV isolation protocol is optimized and the quantity and protein content of EVs induced by different agonists are compared and activation-dependent variations render the use of protein content in sample normalization invalid.