Author
Sabina Passamonti
Other affiliations: University of Padua, National University of Rosario
Bio: Sabina Passamonti is an academic researcher from University of Trieste. The author has contributed to research in topics: Food additive & Medicine. The author has an hindex of 31, co-authored 111 publications receiving 3504 citations. Previous affiliations of Sabina Passamonti include University of Padua & National University of Rosario.
Topics: Food additive, Medicine, Chemistry, Population, Acceptable daily intake
Papers published on a yearly basis
Papers
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TL;DR: It is concluded that the oxidation-reduction state of vicinal thiols in cysteinyl residues plays a critical role in tuning the voltage sensor of the transition pore, with an increase of gating potential as the couple is poised to a more oxidized state.
531 citations
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TL;DR: The ability of grape anthocyanins to permeate the gastric mucosa can be suggested as a possible explanation of the fast kinetics of plasma appearance of anthocaranins in rats and humans as mentioned in this paper.
306 citations
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TL;DR: The identification of a new class of bilitranslocase substrates, i.e., anthocyanins, is reported on, suggesting that bilitanslocase could play a role in the bioavailability of anthOCyanins.
199 citations
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TL;DR: It is demonstrated for the first time that grape pigments can reach the mammalian brain within minutes from their introduction into the stomach and not only in the plasma but also in the brain.
Abstract: Anthocyanins represent the main flavonoid pigments in red grape and wine, in red berries, and in many other fruits and vegetables and are widespread in the human diet. After ingestion, these complex, hydrophilic compounds quickly appear as intact molecules in the plasma. This study investigated their presence in the brain of anesthetized rats that received 8 mg/kg of body weight of a pure anthocyanin mixture extracted from Vitis vinifera grapes. The mixture was maintained in the stomach for 10 min. After this time, intact anthocyanins were detected by HPLC-DAD-MS not only in the plasma (176.4 +/- 50.5 ng/mL, mean +/- SEM) but also in the brain (192.2 +/- 57.5 ng/g). These results demonstrate for the first time that grape pigments can reach the mammalian brain within minutes from their introduction into the stomach.
184 citations
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TL;DR: The general function of bilitranslocase as a flavonoids membrane transporter is demonstrated by the occurrence of a plant homologue in organs where flavonoid biosynthesis is most active, and its relationship with plasma bilirubin (an endogenous antioxidant) is provided.
Abstract: Fruits and vegetables are rich in flavonoids, and ample epidemiological data show that diets rich in fruits and vegetables confer protection against cardiovascular, neurodegenerative and inflammatory diseases, and cancer. However, flavonoid bioavailability is reportedly very low in mammals and the molecular mechanisms of their action are still poorly known. This review focuses on membrane transport of flavonoids, a critical determinant of their bioavailability. Cellular influx and efflux transporters are reviewed for their involvement in the absorption of flavonoids from the gastro-intestinal tract and their subsequent tissue distribution. A focus on the mammalian bilirubin transporter bilitranslocase (TCDB 2.A.65.1.1) provides further insight into flavonoid bioavailability and its relationship with plasma bilirubin (an endogenous antioxidant). The general function of bilitranslocase as a flavonoid membrane transporter is further demonstrated by the occurrence of a plant homologue in organs (petals, berries) where flavonoid biosynthesis is most active. Bilitranslocase appears associated with sub-cellular membrane compartments and operates as a flavonoid membrane transporter.
176 citations
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TL;DR: The nature and contents of the various polyphenols present in food sources and the influence of agricultural practices and industrial processes are reviewed, and bioavailability appears to differ greatly between the variousPolyphenols, and the most abundantpolyphenols in the authors' diet are not necessarily those that have the best bioavailability profile.
6,842 citations
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01 Jan 1979
5,044 citations
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TL;DR: Gallic acid and isoflavones are the most well-absorbed polyphenols, followed by catechins, flavanones, and quercetin glucosides, but with different kinetics, and the least well- absorption polyphenol are the proanthocyanidins, the galloylated tea catech ins, andThe anthocyanins.
3,534 citations
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TL;DR: It is suggested that long term consumption of diets rich in plant polyphenols offer protection against development of cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases.
Abstract: Polyphenols are secondary metabolites of plants and are generally involved in defense against ultraviolet radiation or aggression by pathogens. In the last decade, there has been much interest in the potential health benefits of dietary plant polyphenols as antioxidant. Epidemiological studies and associated meta-analyses strongly suggest that long term consumption of diets rich in plant polyphenols offer protection against development of cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases. Here we present knowledge about the biological effects of plant polyphenols in the context of relevance to human health.
3,370 citations
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2,374 citations