Sabine Heinisch

TL;DR: Grafted MCM-41 materials are ordered mesoporous adsorbents suitable for reversed phase liquid chromatography applications (RP-HPLC): they possess high surface area, which is a great advantage to enhance the thermodynamic behavior of the classical stationary phase by increasing solute retention.

TL;DR: The objective of this review is to give an overview of past, current and emerging trends in 2D‐LC techniques applied to pharmaceutical compounds to predict future advances in two‐dimensional separation techniqes for pharmaceutical analysis.

TL;DR: An innovative multidimensional analytical approach combining comprehensive online two-dimensional (2D)-chromatography that consists of HIC and size-exclusion chromatography (SEC), to ion mobility and mass spectrometry (IM-MS) for performing analytical characterization of ADCs under nondenaturing conditions is presented.

TL;DR: The goal of this review is to describe the various SFC-MS interfaces and highlight the most favorable ones in terms of reliability, flexibility, sensitivity and user-friendliness.

TL;DR: The commercial C18 columns packed with sub-3 μm shell particles were tested and compared to a reference UHPLC column, in terms of kinetic performance as well as selectivity, retention capability, peak shape and loading capacity, and a set of pharmaceutically relevant molecules was selected.