S
Sabrina Christiansen
Researcher at University of Hamburg
Publications - 8
Citations - 47
Sabrina Christiansen is an academic researcher from University of Hamburg. The author has contributed to research in topics: Head and neck squamous-cell carcinoma & Medicine. The author has an hindex of 2, co-authored 3 publications receiving 11 citations.
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Journal ArticleDOI
The inflammation-reducing compatible solute ectoine does not impair the cytotoxic effect of ionizing radiation on head and neck cancer cells.
TL;DR: Using HNSCC cell lines and primary human fibroblasts, it is shown that in living cells ectoine does not impair DNA damage induction and cytotoxicity through ionizing radiation and testing the ectopic application of ectoine for its ability to alleviate early radiotherapy/chemoradiation-induced side effects is safe and feasible.
Journal ArticleDOI
Patient derived ex vivo tissue slice cultures demonstrate a profound DNA double-strand break repair defect in HPV-positive oropharyngeal head and neck cancer.
Henrike Barbara Zech,J. Berger,Wael Y. Mansour,Lena Nordquist,Clara Marie von Bargen,Lara Bußmann,Agnes Oetting,Sabrina Christiansen,Nikolaus Möckelmann,Arne Böttcher,Chia-Jung Busch,Cordula Petersen,Christian Betz,Kai Rothkamm,Malte Kriegs,Sabrina Köcher,Thorsten Rieckmann +16 more
TL;DR: In this article , DNA double-strand break (DSB) repair deficiency in head and neck squamous cell carcinoma of the oropharynx (OPSCC) was found to contribute to enhanced clinical radiosensitivity.
Journal ArticleDOI
Dual Inhibition of PARP and the Intra-S/G2 Cell Cycle Checkpoints Results in Highly Effective Radiosensitization of HPV-Positive HNSCC Cells.
Katharina Hintelmann,Thomas Berenz,Malte Kriegs,Sabrina Christiansen,Fruzsina Gatzemeier,Nina Struve,Cordula Petersen,Christian Stephan Betz,Kai Rothkamm,Agnes Oetting,Thorsten Rieckmann +10 more
TL;DR: In this paper, a combination of PARP and the DNA damage-induced intra-S/G2 cell cycle checkpoints was used for radiosensitization of head and neck squamous cell carcinoma (HNSCC) cells.
Journal ArticleDOI
Radiosensitisation and enhanced tumour growth delay of colorectal cancer cells by sustained treatment with trifluridine/tipiracil and X-rays
Kai Rothkamm,Sabrina Christiansen,Thorsten Rieckmann,Michael Horn,Thorsten Frenzel,Alexandra Brinker,Udo Schumacher,Alexander Stein,Cordula Petersen,Susanne Burdak-Rothkamm +9 more
TL;DR: The strong radiosensitising effect observed in vitro after prolonged treatment with FTD/TPI and equivalence with capecitabine-based chemoradiation in vivo support a daily fractionated combined regime of FTD/(TPI) and radiation in rectal cancer treatment.
Journal ArticleDOI
A Lack of Effectiveness in the ATM-Orchestrated DNA Damage Response Contributes to the DNA Repair Defect of HPV-Positive Head and Neck Cancer Cells
Sabrina Köcher,Henrike Barbara Zech,Leonie Krug,Fruzsina Gatzemeier,Sabrina Christiansen,Felix Meyer,Ruth Rietow,Nina Struve,Wael Y. Mansour,Malte Kriegs,Cordula Petersen,Christian Betz,Kai Rothkamm,Thorsten Rieckmann +13 more
TL;DR: DNA repair kinetics and a reduced effectiveness of ATM inhibition clearly point to an impaired ATM-orchestrated DNA damage response in HPV+ HNSCC cells, but since ATM itself is apparently functional, the molecular mechanisms need to be further explored.