S
Sabrina Le Bouter
Researcher at French Institute of Health and Medical Research
Publications - 14
Citations - 2339
Sabrina Le Bouter is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Atrial fibrillation & Repolarization. The author has an hindex of 13, co-authored 14 publications receiving 2173 citations. Previous affiliations of Sabrina Le Bouter include Montreal Heart Institute & Centre national de la recherche scientifique.
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Journal ArticleDOI
Arrhythmogenic Ion-Channel Remodeling in the Heart: Heart Failure, Myocardial Infarction, and Atrial Fibrillation
TL;DR: The changes in ion channel and transporter properties associated with three important clinical and experimental paradigms: congestive heart failure, myocardial infarction, and atrial fibrillation are reviewed and important opportunities for improved therapeutic approaches are highlighted.
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Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart
Nathalie Gaborit,Nathalie Gaborit,Sabrina Le Bouter,Viktoria Szuts,András Varró,András Varró,Denis Escande,Stanley Nattel,Sophie Demolombe +8 more
TL;DR: The first report of the global portrait of regional ion‐channel subunit‐gene expression in the non‐diseased human heart is presented, with potentially important implications for understanding regional electrophysiology, arrhythmia mechanisms, and responses to ion‐ channel blocking drugs.
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Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation.
Nathalie Gaborit,Marja Steenman,Guillaume Lamirault,Nolwenn Le Meur,Sabrina Le Bouter,Gilles Lande,Jean J. Leger,Flavien Charpentier,Torsten Christ,Dobromir Dobrev,Denis Escande,Stanley Nattel,Sophie Demolombe +12 more
TL;DR: VHD extensively remodels cardiac ion-channel and transporter expression, and AF alters ion-Channel expression in VHD patients.
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Mouse model of SCN5A-linked hereditary lenègre's disease : Age-related conduction slowing and myocardial fibrosis
Anne Royer,Toon A.B. van Veen,Sabrina Le Bouter,Céline Marionneau,Violaine Griol-Charhbili,Anne-Laure Leoni,Marja Steenman,Harold V.M. van Rijen,Sophie Demolombe,C. A. Goddard,Christine Richer,Brigitte Escoubet,Thérèse Jarry-Guichard,William H. Colledge,Daniel Gros,Jacques M.T. de Bakker,Andrew A. Grace,Denis Escande,Flavien Charpentier +18 more
TL;DR: This work provides the first demonstration that a monogenic ion channel defect can progressively lead to myocardial structural anomalies, including progressive impairment with aging of atrial and ventricular conduction associated withMyocardial rearrangements and fibrosis.
Journal ArticleDOI
Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts.
Nathalie Gaborit,Nathalie Gaborit,Nathalie Gaborit,András Varró,András Varró,Sabrina Le Bouter,Sabrina Le Bouter,Sabrina Le Bouter,Viktoria Szuts,Denis Escande,Denis Escande,Denis Escande,Stanley Nattel,Sophie Demolombe,Sophie Demolombe,Sophie Demolombe +15 more
TL;DR: The results indicate that male and female human hearts have significant differences in ion-channel subunit composition, with female hearts showing decreased expression for a number of repolarizing ion-channels.