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Author

Sai S. Sagiri

Other affiliations: Department of Biotechnology
Bio: Sai S. Sagiri is an academic researcher from National Institute of Technology, Rourkela. The author has contributed to research in topics: Self-healing hydrogels & Drug delivery. The author has an hindex of 22, co-authored 46 publications receiving 1063 citations. Previous affiliations of Sai S. Sagiri include Department of Biotechnology.

Papers published on a yearly basis

Papers
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Journal ArticleDOI
TL;DR: Attempts have been made to understand the properties of organogels, various types oforganogelators and some applications of the organogelels in controlled delivery.
Abstract: An organogel, a viscoelastic system, can be regarded as a semi-solid preparation which has an immobilized external apolar phase. The apolar phase is immobilized within spaces of the three-dimensional network structure formed due to the physical interactions amongst the self-assembling structures of compounds regarded as gelators. In general, organogels are thermodynamically stable in nature and have been explored as matrices for the delivery of bioactive agents. In the current paper, attempts have been made to understand the properties of organogels, various types of organogelators and some applications of the organogels in controlled delivery.

136 citations

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TL;DR: The role of stearic acid on physic-chemical properties of oleogel was investigated and it was indicated that heterogeneous nucleation was coupled with the one-dimensional growth of gelator fibers as the key phenomenon in the formation of Oleogels.

109 citations

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TL;DR: This review provides thorough insight into different organogelators, their mechanisms of organogels formation, various characterization techniques and their biocompatibility when administered in vivo.
Abstract: Over the last two decades, organogels have found tremendous use in the pharmaceutical, food, and cosmetics industries with notable developments as drug delivery matrices and trans and saturated fat replacers in processed foods. The functionality of organogels benefits from their ease of preparation, cost effectiveness, and ability to contain both hydrophilic and lipophilic constituents. This review provides thorough insight into different organogelators, their mechanisms of organogel formation, various characterization techniques and their biocompatibility when administered in vivo. Finally, a special treatise is given on the applications of organogels as controlled drug delivery vehicles for topical, dermal/transdermal, parenteral, oral, and nasal routes. In situ forming organogels and their potential for tailored release of incorporated active ingredients are also discussed.

101 citations

Journal ArticleDOI
TL;DR: Bigels synthesized by mixing gelatin hydrogel and stearic acid based organogel by hot emulsification method may have huge potential to be used as alternatives to emulgels.
Abstract: Over the past decade, researchers have been trying to develop alternative gel based formulations in comparison to the traditional hydrogels and emulgels. In this perspective, bigels were synthesized by mixing gelatin hydrogel and stearic acid based organogel by hot emulsification method. Two types of bigels were synthesized using sesame oil and soy bean oil based stearate organogels. Gelatin based emulgels prepared using sesame oil and soy bean oil were used as the controls. Microscopic studies revealed that the bigels contained aggregates of droplets, whereas, emulgels showed dispersed droplets within the continuum phase. The emulgels showed higher amount of leaching of oils, whereas, the leaching of the internal phase was negligible from the bigels. Presence of organogel matrix within the bigels was confirmed by XRD, FTIR and DSC methods. Bigels showed higher mucoadhesive and mechanical properties compared to emulgels. Cyclic creep-recovery and stress relaxation studies confirmed the viscoelastic nature of the formulations. Four elemental Burger's model was employed to analyze the cyclic creep-recovery data. Cyclic creep-recovery studies suggested that the deformation of the bigels were lower due to the presence of the organogels within its structure. The formulations showed almost 100% recovery after the creep stage and can be explained by the higher elastic nature of the formulations. Stress relaxation study showed that the relaxation time was higher in the emulgels as compared to the bigels. Also, the % relaxation was higher in emulgels suggesting its fluid dominant nature. The in vitro biocompatibility of the bigels was checked using human epidermal keratinocyte cell line (HaCaT). Both emulgels and bigels were biocompatible in nature. The in vitro drug (ciprofloxacin) release behavior indicated non-Fickian diffusion of the drug from the matrices. The drug release showed good antimicrobial effect against Escherichia coli. Based on the results, it was concluded that the developed bigels may have huge potential to be used as alternatives to emulgels.

72 citations

Journal ArticleDOI
TL;DR: The etiology and the various present-day modalities of treatment of bacterial vaginosis, either separately or in combination are discussed.
Abstract: A large women population of the world is suffering from a vaginal infection commonly known as bacterial vaginosis. The disease is associated with the decrease in the lactobacilli count in the vagina. Till date, there is a lack of full proof treatment modalities for the cure of the disease. The treatment includes the use of antimicrobials and/or acidifying agents and probiotics, either separately or in combination. This note discusses about the etiology and the various present-day modalities of treatment of bacterial vaginosis.

55 citations


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Journal ArticleDOI
TL;DR: This review gives an overview of relevant properties of alginate as oral colon delivery systems and the recent innovative strategies of usingAlginate with other polymers as well as microencapsulation techniques and describes the several advantages of coating processes involving alginates over microparticles in order to design better material with sustained release characteristic for colon-targeted delivery.

294 citations

Journal ArticleDOI
TL;DR: This review article focuses on versatile mechanisms for gelation of globular proteins and highlights the current studies on whey and soy protein hydrogels as two key animal and herbal proteins used in fabricating coating materials.
Abstract: Background Bioactive molecules are mostly amenable to degradation at processing, storage, and harsh digestion conditions. Hence, high-throughput encapsulation bodies must be designed in a way to protect them from destructive circumstances and to enhance their bioavailability. Scope and approach This review article focuses on versatile mechanisms for gelation of globular proteins and highlights the current studies on whey and soy protein hydrogels as two key animal and herbal proteins used in fabricating coating materials. Moreover, different categories of hydrogels, such as aerated hydrogels, hydrogels made from aggregated forms of proteins, hydrogels originated from food-grade materials, and hydrogels with nano scale dimensions are discussed. Key findings and conclusions The gelation and particulation method have dramatic effects on the liberation features as well as the bioactivity of the wrapped ingredients. Therefore, different approaches are needed to be considered in order to increase the bioavailability of nutraceuticals and drugs accommodated within protein hydrogels. Accordingly, there is a growing trend for developing innovative modes of gelation and immobilizing bioactive materials into the hydrogel network.

237 citations

Journal ArticleDOI
TL;DR: In this article, the stability mechanism of liquid water-in-oil emulsions was investigated in different systems, and the combination of two different oils (soybean oil and hexadecane) and three emulsifiers (PGPR, Span 80 and lecithin) at two water:oil ratios was investigated.

221 citations

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TL;DR: The current review intends to overview the studies in which wound dressings from naturally-occurring polymers, based on homopolysaccharides, were prepared and evaluated.

216 citations

Journal ArticleDOI
TL;DR: In this paper, the use of gliadin colloid particles (GCPs) as an effective particulate stabilizer of oil-in-water emulsions of natural oils and water was demonstrated.

212 citations