S
Saïk Urien
Researcher at University of Paris
Publications - 181
Citations - 4131
Saïk Urien is an academic researcher from University of Paris. The author has contributed to research in topics: Population & Pharmacokinetics. The author has an hindex of 34, co-authored 173 publications receiving 3748 citations. Previous affiliations of Saïk Urien include French Institute of Health and Medical Research & Paris Descartes University.
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Drug binding in plasma. A summary of recent trends in the study of drug and hormone binding.
TL;DR: The ligands are generally bound in plasma to a significant extent by several transport proteins (both high and low affinity), irrespective of their endogenous or exogenous origin, and the physiological significance of the high-affinity transport proteins is not completely understood.
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Tim-3 expression on tumor-infiltrating PD-1+CD8+T cells correlates with poor clinical outcome in renal cell carcinoma
Clémence Granier,Charles Dariane,Pierre Combe,Virginie Verkarre,Saïk Urien,Cécile Badoual,Hélène Roussel,Marion Mandavit,Patrice Ravel,Mathilde Sibony,Lucie Biard,Camelia Radulescu,Emeline Vinatier,Emeline Vinatier,Nadine Benhamouda,Nadine Benhamouda,Michaël Peyromaure,Stéphane Oudard,Arnaud Mejean,Marc Olivier Timsit,Alain Gey,Alain Gey,Eric Tartour,Eric Tartour +23 more
TL;DR: These findings establish intratumoral Tim-3+PD1+CD8+ T cells as critical mediators of an aggressive phenotype in RCC and use of the Vectra tool may be useful to identify similarly critical prognostic and predictive biomarkers in other tumor types and their response to immunotherapy.
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Population pharmacokinetics and bioavailability of tacrolimus in kidney transplant patients
TL;DR: The number of days postoperation and corticosteroid dose were significant covariates influencing tacrolimus clearance, and the one compartment open model with linear absorption and elimination adequately described the data.
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Docetaxel serum protein binding with high affinity to alpha 1-acid glycoprotein.
TL;DR: It was concluded that alpha1-acid glycoprotein should be the main determinant of docetaxel plasma binding variability and was found to be mainly located in the plasma compartment.
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Concentrations of Tenofovir and Emtricitabine in Breast Milk of HIV-1-Infected Women in Abidjan, Côte d'Ivoire, in the ANRS 12109 TEmAA Study, Step 2
Sihem Benaboud,Sihem Benaboud,Alain Pruvost,Patrick A. Coffie,Didier K. Ekouevi,Saïk Urien,Saïk Urien,Elise Arrivé,Stéphane Blanche,Frédéric Théodoro,Divine Avit,François Dabis,Jean-Marc Treluyer,Jean-Marc Treluyer,Déborah Hirt +14 more
TL;DR: In this paper, the authors evaluated emtricitabine (FTC) and tenofovir (TFV) neonatal ingestion through breast milk and found that TFV was extremely low for TFV but between the half-maximal inhibitory concentration and the adult minimal expected concentration for FTC.