Sakineh Dadashpour

TL;DR: The current developments of coumarin-based anticancer agents are covered and the structure-activity relationship of the most potent compounds are discussed.

TL;DR: The present article aims to review the current application of indole core in the design of new anticancer agents that may act via various targets such as histone deacetylases, sirtuins, PIM kinases, DNA topoisomerases and σ receptors.

TL;DR: A series of 5,6-bisaryl-1,2,4-triazine-3-thiol derivatives were synthesized through microwave-promoted chemistry by condensation of the aromatic 1,2-diketones and thiosemicarbazide in a mixed green solvent.

TL;DR: In order to find novel cyclooxygenase (COX)‐2 inhibitors for treating inflammatory‐based diseases such as Alzheimer's disease, an ethyl carboxylate side chain was added to 5‐(4‐chlorophenyl)‐6‐(3‐methylsulfonyl)‐3‐(methylthio)‐1,2,4‐triazine (lead compound II) to maintain residual inhibition of COX‐1 through interacting with Arg120.

TL;DR: Conformational study of compound 3 and subsequent docking of its restrained analogs on both active sites of COX‐1 andCOX‐2 could provide a proof of its COX•1 selectivity as well as molecular dynamic simulation could elucidate and give more insight into the amyloid disaggregation mechanisms leading to rational design of inhibitors.