Author
Saliha Alyar
Other affiliations: Gazi University
Bio: Saliha Alyar is an academic researcher from Çankırı Karatekin University. The author has contributed to research in topics: Carbon-13 NMR & Carbonic anhydrase II. The author has an hindex of 14, co-authored 23 publications receiving 346 citations. Previous affiliations of Saliha Alyar include Gazi University.
Papers
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TL;DR: In this paper, new Schiff bases were synthesized (Z)-4-((4-(diethylamino)benzylidene)amino)-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide (L1) and (Z]-4-(4-(dimethylamino), amino amino) amino)-n-(5-methylisoxosol-3-yl), N-(5 -methylisocazol)-3 -yl)benedienesulfoneamide (
45 citations
TL;DR: Schiff bases and 1,8-bis(thiophene-2-carboxaldimine)-p-menthane (L1 and L2) have been synthesized and characterized by elemental analysis, 1H 13C NMR, UV-vis, FT-IR and LC-MS methods as discussed by the authors.
41 citations
TL;DR: A series of aromatic disulfonamide derivatives and 4-methylbenzenesulfonyl hydrazide were synthesized and characterized and showed that the most active compound possessed low lipophilicity and high solubility.
Abstract: A series of aromatic disulfonamide (1-8) derivatives and 4-methylbenzenesulfonyl hydrazide (9) were synthesized and characterized. All compounds were evaluated in vitro for their antimicrobial activity against Staphylococcus aureus ATCC 25953, Bacillus cereus ATCC 6633, Bacillus magaterium RSKK 5117, Escherichia coli ATCC 11230, Salmonella enterititis ATCC 13076 by microdilution and disc diffusion methods. Antimicrobial activity of the aromatic disulfonamides decreased as the length of the carbon chain increased. An analysis of the structure- activity relationship (SAR) along with computational studies showed that the most active compound (9) possessed low lipophilicity (AlogP=0.59) and high solubility (logS = -1.33).
33 citations
TL;DR: Four-parameter QSAR models revealed that nucleophilic reaction index for Ni and O atoms, and HOMO-LUMO energy gap play key roles in the antimicrobial activity.
32 citations
TL;DR: In this paper, the synthesis of new Schiff bases (E) N-(3,4-dimethylisoxazol-5-yl)-4-((2-hydroxy-4-methoxybenzylidene)amino)benzenesulfonamide (L2), N-(5-methylisoxozol-3-yl)benzene sulfonamide(L3), and substituted salicylaldehydes and their Pd (II), Cu (II) complexes were synthesized for the first time.
30 citations
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2,177 citations
TL;DR: In this paper, bidentate chelating agents N,N′-(ethane-1,2-diyl)bis(4-methoxybenzene sulfonamide) [EDBMBS] were synthesized in order to detect and remove toxic Ni2+ from water samples.
132 citations
12 Nov 2014
TL;DR: The aim of this review is to focus on the structure and biological functions of bovine serum albumin, the design of metal complexes that are able to bind to the biomolecule, as well as the experimental techniques employed in the study and evaluation of these interactions.
Abstract: The continuous search for new molecules with therapeutic abilities has led to the synthesis and characterization of a large number of metal complexes, proven to exhibit potential as pharmacological agents through their antibacterial, antiviral, antifungal and antineoplastic properties. As serum albumins play a key role in drug pharmacokinetics and pharmacodynamics, the study of coordination compounds affinity towards this class of proteins, as well as understanding the mechanism through which they interact is crucial. The aim of this review is to focus on the structure and biological functions of bovine serum albumin, the design of metal complexes that are able to bind to the biomolecule, as well as the experimental techniques employed in the study and evaluation of these interactions.
125 citations
TL;DR: The theoretical calculations of Benzyl-3-N-(2,4,5-trimethoxyphenylmethylene)hydrazinecarbodithioate and in silico studies predicted that the compound has good drug like character.
124 citations