Effects of the intraperitoneal injection of quercetin in streptozocin-induced diabetic and normal rats were investigated and compared. Although quercetin had no effect on plasma glucose level of normal animals, it significantly and dose-dependently decreased the plasma glucose level of streptozocin-induced diabetic rats. Glucose tolerance tests of the diabetic animals approached those of normal rats, their plasma cholesterol and triglycerides were reduced significantly, while their hepatic glucokinase activity was significantly increased upon quercetin treatment. In normal rats, quercetin did not affect the glucose tolerance test, but resulted in an increase of plasma cholesterol and triglycerides and a decrease in hepatic glucokinase activity. No significant pathologic changes were noted in hepatocytes or kidney tubules and glomeruli, while the number of pancreatic islets significantly increased in both treated normal and diabetic groups. It is concluded that quercetin, a flavonoid with antioxidant properties brings about the regeneration of the pancreatic islets and probably increases insulin release in streptozocin-induced diabetic rats; thus exerting its beneficial antidiabetic effects. However, it may be of little value in normoglycemic animals.

Antidiabetic effects of quercetin in streptozocin-induced diabetic rats.

Relation between serum-free-fatty-acids and arrhythmias and death after acute myocardial infarction

Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and β-carotene

Biochemical study on the hypoglycemic effects of onion and garlic in alloxan-induced diabetic rats

(1973). Laboratory Tests for the Assessment of Nutritional Status. CRC Critical Reviews in Clinical Laboratory Sciences: Vol. 4, No. 3, pp. 215-340.

Laboratory Tests for the Assessment of Nutritional Status

A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

Gradwohl's Clinical laboratory methods and diagnosis; a textbook on laboratory procedures and their interpretation , Gradwohl's Clinical laboratory methods and diagnosis; a textbook on laboratory procedures and their ... , مرکز فناوری اطلاعات و اطلاع رسانی کشاورزی

Gradwohl's Clinical laboratory methods and diagnosis;: A textbook on laboratory procedures and their interpretation

The range of 82 to 92 cu. μ . generally accepted as normal for mean corpuscular volume (MCV) in the United States was found to be too low when determinations were made with the Model S Coulter Counter. The mean MCV for 200 blood specimens from a mixed population was 91.4 cu. μ , with a normal range of 84 to 99 cu. μ . This is in close agreement with the findings of another independent study in which MCV was calculated from manually obtained hematocrits and erythrocyte counts.

Normal values for mean corpuscular volume as determined by the Model S Coulter Counter.

The storage capability of the sterile Corvac® silicone gel tube as a specimen collection device is evaluated. Sera collected and stored in sterile Corvac silicone gel tubes were compared with control specimens collected in regular Monoject® tubes and transferred to new Monoject tubes for storage. Sera for the efficacy tests were transferred from both the gel tube and the control tube without concern for storage. Sixty-seven analytes were compared, 20 of which were included in the storage portion. Only glucose, potassium, carbon dioxide, phosphorus, alkaline phosphatase, and lactic acid dehydrogenase (LDH) were statistically different in the storage experiment and amylase, T-3 uptake, folates, HDL, and again LDH by another method, were statistically different in the efficacy experiment. These evaluations determine the validity of storing specimens in this manner for reanalysis or additional analyses.

Sam Frankel

Papers

A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases.

Gradwohl's Clinical laboratory methods and diagnosis;: A textbook on laboratory procedures and their interpretation

Normal values for mean corpuscular volume as determined by the Model S Coulter Counter.

Sterile Corvac silicone gel tubes: efficacy and storage capabilities.